Synthesis of azetidin-2-one derivatives as inhibitor of secretory phospholipase A2 with anti-inflammatory activity

被引：0

作者：

Yerigeri, MC ^{[1
]}

Murari, SK

Mohammed, S

Math, SKS

Thimmaiah, KN

Vishwanath, BS

机构：

[1] VL Coll Pharm, Dept Med Chem, Raichur 584103, India

[2] Western Illinois Univ, Dept Chem, Macomb, IL 61455 USA

[3] Univ Mysore, Dept Studies Biochem, Mysore 570006, Karnataka, India

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2005年 / 2卷 / 04期

关键词：

phospholipase A(2) (PLA(2)); anti-inflammatory; azetidin-2-one derivatives;

D O I：

10.2174/1570180054038404

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The title compounds have been synthesized and tested for structure activity relationship for Phospholipase A(2) (PLA(2)) [E.C. 3.1.1.4] enzyme inhibition. The in vitro PLA(2) enzyme inhibitory activity of azetidin-2-one derivatives and in vivo anti-inflammatory activity studies using mice are highlighted. The results show that some azetidin-2-one derivatives are very good PLA(2) inhibitors and can also be used as anti-inflammatory drugs.

引用

页码：307 / 310

页数：4

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