Chemical etiology of nucleic acid structure

被引：452

作者：

Eschenmoser, A

机构：

[1] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[2] Swiss Fed Inst Technol, Organ Chem Lab, CH-8092 Zurich, Switzerland

来源：

SCIENCE | 1999年 / 284卷 / 5423期

关键词：

D O I：

10.1126/science.284.5423.2118

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Systematic chemical studies indicate that the capability of Watson-Crick base-pairing is widespread among potentially natural nucleic acid alternatives taken from RNA's close structural neighborhood. A comparison of RNA and such alternatives with regard to chemical properties that are fundamental to the biological function of RNA provides chemical facts that may contain clues to RNA's origin.

引用

页码：2118 / 2124

页数：7

共 113 条

[41]

Joyce GF., 1999, RNA WORLD, P49

[42]

JUNGMANN O, UNPUB

[43]

KAUFFMAN SA, 1993, ORIGINS ORDER SELFOR

[44] ASSOCIATION OF 2'-5' OLIGORIBONUCLEOTIDES [J].