Asymmetric mesoporous silica nanoparticles as potent and safe immunoadjuvants provoke high immune responses

被引：42

作者：

Abbaraju, Prasanna Lakshmi ^{[1
]}

Jambhrunkar, Manasi ^{[1
]}

Yang, Yannan ^{[1
]}

Liu, Yang ^{[1
]}

Lu, Yao ^{[1
]}

Yu, Chengzhong ^{[1
]}

机构：

[1] Univ Queensland, Australian Inst Bioengn & Nanotechnol, Brisbane, Qld 4072, Australia

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 16期

关键词：

GOLD NANOPARTICLES; VACCINE ADJUVANT; IN-VIVO; PEPTIDE; CELLS; NANOCOMPOSITES; ACTIVATION; MEMORY; SHAPE;

D O I：

10.1039/c8cc00327k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Asymmetric mesoporous silica nanoparticles with a head-tail structure are potent immunoadjuvants for delivering a peptide antigen, generating a higher antibody immune response in mice compared to their symmetric counterparts.

引用

页码：2020 / 2023

页数：4

共 37 条

[11] Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy [J].

Kim, Jaeyun ;

Li, Weiwei Aileen ;

Choi, Youngjin ;

Lewin, Sarah A. ;

Verbeke, Catia S. ;

Dranoff, Glenn ;

Mooney, David J. .

NATURE BIOTECHNOLOGY, 2015, 33 (01) :64-U241

[12] The effect of surface modification of mesoporous silica micro-rod scaffold on immune cell activation and infiltration [J].

Li, Weiwei Aileen ;

Lu, Beverly Ying ;

Gu, Luo ;

Choi, Youngjin ;

Kim, Jaeyun ;

Mooney, David J. .

BIOMATERIALS, 2016, 83 :249-256

[13] Anisotropic Encapsulation-Induced Synthesis of Asymmetric Single-Hole Mesoporous Nanocages [J].

Li, Xiaomin ;

Zhou, Lei ;

Wei, Yong ;

El-Toni, Ahmed Mohamed ;

Zhang, Fan ;

Zhao, Dongyuan .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2015, 137 (18) :5903-5906

[14]

Li ZY, 2003, BIOL REPROD, V68, P208

[15] Hyaluronic Acid-Modified Cationic Lipid-PLGA Hybrid Nanoparticles as a Nanovaccine Induce Robust Humoral and Cellular Immune Responses [J].

Liu, Lanxia ;

Cao, Fengqiang ;

Liu, Xiaoxuan ;

Wang, Hai ;

Zhang, Chao ;

Sun, Hongfan ;

Wang, Chun ;

Leng, Xigang ;

Song, Cunxian ;

Kong, Deling ;

Ma, Guilei .

ACS APPLIED MATERIALS & INTERFACES, 2016, 8 (19) :11969-11979

[16] Role of Metallic Nanoparticles in Vaccinology: Implications for Infectious Disease Vaccine Development [J].

Marques Neto, Lazaro Moreira ;

Kipnis, Andre ;

Junqueira-Kipnis, Ana Paula .

FRONTIERS IN IMMUNOLOGY, 2017, 8

[17] Gold Nanoparticles as a Vaccine Platform: Influence of Size and Shape on Immunological Responses in Vitro and in Vivo [J].

Niikura, Kenichi ;

Matsunaga, Tatsuya ;

Suzuki, Tadaki ;

Kobayashi, Shintaro ;

Yamaguchi, Hiroki ;

Orba, Yasuko ;

Kawaguchi, Akira ;

Hasegawa, Hideki ;

Kajino, Kiichi ;

Ninomiya, Takafumi ;

Ijiro, Kuniharu ;

Sawa, Hirofumi .

ACS NANO, 2013, 7 (05) :3926-3938

[18]

Ogra PL, 2001, CLIN MICROBIOL REV, V14, P641

[19] A Facile Synthesis of Asymmetric Hybrid Colloidal Particles [J].

Ohnuma, Akira ;

Cho, Eun Chul ;

Camargo, Pedro H. C. ;

Au, Leslie ;

Ohtani, Bunsho ;

Xia, Younan .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (04) :1352-+

[20] A lipid core peptide construct containing a conserved region determinant of the group a streptococcal M protein elicits heterologous opsonic antibodies [J].

Olive, C ;

Batzloff, MR ;

Horváth, A ;

Wong, A ;

Clair, T ;

Yarwood, P ;

Toth, I ;

Good, MF .

INFECTION AND IMMUNITY, 2002, 70 (05) :2734-2738

← 1 2 3 4 →