Glioblastoma Multiforme Treatment with Clinical Trials for Surgical Resection (Aminolevulinic Acid)

被引：47
作者：
Roberts, David W. [1 ,2 ,3 ]
Valdes, Pablo A. [1 ,2 ,4 ]
Harris, Brent T. [5 ]
Hartov, Alexander [3 ,4 ]
Fan, Xiaoyao [3 ,4 ]
Ji, Songbai [3 ,4 ]
Leblond, Frederic [3 ,4 ]
Tosteson, Tor D. [2 ,3 ]
Wilson, Brian C. [6 ]
Paulsen, Keith D. [3 ,4 ]
机构：
[1] Dartmouth Hitchcock Med Ctr, Neurosurg Sect, Lebanon, NH 03756 USA
[2] Dartmouth Coll, Hitchcock Med Ctr, Dartmouth Med Sch, Hanover, NH 03756 USA
[3] Norris Cotton Canc Ctr, Lebanon, NH USA
[4] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA
[5] Georgetown Univ, Med Ctr, Dept Pathol & Neurol, Washington, DC 20007 USA
[6] Univ Toronto, Dept Med Biophys, Ontario Canc Inst, Toronto, ON, Canada
来源：
NEUROSURGERY CLINICS OF NORTH AMERICA | 2012年 / 23卷 / 03期
基金：
美国国家卫生研究院;
关键词：
5-ALA; Fluorescence; Glioma; Surgery; RECURSIVE PARTITIONING ANALYSIS; FLUORESCENCE-GUIDED RESECTION; 5-AMINOLEVULINIC ACID; MALIGNANT GLIOMA;
D O I：
10.1016/j.nec.2012.04.001
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
5-Aminolevulinic acid (5-ALA)-induced tumor fluorescence can be used to identify tissue for resection using an adapted operating microscope. A multi-institutional clinical trial comparing fluorescence-guided versus white light tumor resection reported significant improvement in completeness of resection and 6-month progression-free survival. The degree of 5-ALA-induced fluorescence correlates with histopathologic grade of tumor, degree of tumor cell infiltration, and proliferation indices. Quantitative methodologies for assessment of tissue fluorescence have significantly improved the ability to detect tumor tissue and intraoperative diagnostic performance. These developments extend the applicability of this technology to additional tumor histologies and provide the rationale for further instrumentation development.
引用
收藏
页码：371 / +
页数：8
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