FDG-PET in Early AD Diagnosis

被引：11

作者：

Chew, Jessica ^{[1
]}

Silverman, Daniel H. S. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Mol & Med Pharmacol, Ahmanson Translat Imaging Div, Los Angeles, CA 90095 USA

来源：

MEDICAL CLINICS OF NORTH AMERICA | 2013年 / 97卷 / 03期

关键词：

Alzheimer disease; Dementia; Prodromal diagnosis; Fluorodeoxyglucose; PET; Progression; Multimodal imaging; POSITRON-EMISSION-TOMOGRAPHY; MILD COGNITIVE IMPAIRMENT; ALZHEIMERS ASSOCIATION WORKGROUPS; MEDIAL TEMPORAL ATROPHY; FRONTOTEMPORAL DEMENTIA; NATIONAL INSTITUTE; PERFUSION SPECT; DISEASE; FLUORODEOXYGLUCOSE; RECOMMENDATIONS;

D O I：

10.1016/j.mcna.2012.12.016

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

F-18-fludeoxyglucose positron emission tomography (FDG-PET) is an important tool for detecting the early stages of Alzheimer disease (AD). This article discusses the multiple roles FDG-PET plays in helping to diagnose AD, including detecting the disease in the prodromal and early dementia stages, differential diagnosis of dementia, documenting and quantifying cognitive decline, and predicting progression from mild cognitive impairment to AD. In addition, the role of structural magnetic resonance imaging, underutilization of FDG-PET, and a suggested multimodal approach for early AD diagnosis are discussed.

引用

页码：485 / +

页数：11

共 49 条

[1] 2012 Alzheimer's disease facts and figures [J].

ALZHEIMERS & DEMENTIA, 2012, 8 (02) :131-168

[2] Prodromal Alzheimer's Disease: Successive Emergence of the Clinical Symptoms [J].

Amieva, Helene ;

Le Goff, Melanie ;

Millet, Xavier ;

Orgogozo, Jean Marc ;

Peres, Karine ;

Barberger-Gateau, Pascale ;

Jacqmin-Gadda, Helene ;

Dartigues, Jean Francois .

ANNALS OF NEUROLOGY, 2008, 64 (05) :492-498

[3]

Boeve Bradley F, 2012, Parkinsonism Relat Disord, V18 Suppl 1, pS41, DOI 10.1016/S1353-8020(11)70015-3

[4] The dynamics of Alzheimer's disease biomarkers in the Alzheimer's Disease Neuroimaging Initiative cohort [J].

Caroli, A. ;

Frisoni, G. B. .

NEUROBIOLOGY OF AGING, 2010, 31 (08) :1263-1274

[5] Overtime reliability of medial temporal lobe atrophy rating in a clinical setting [J].

Cavallin, Lena ;

Loken, Kirsti ;

Engedal, Knut ;

Oksengard, Anne-Rita ;

Wahlund, Lars-Olof ;

Bronge, Lena ;

Axeisson, Rimma .

ACTA RADIOLOGICA, 2012, 53 (03) :318-323

[6] Characterizing Alzheimer's disease using a hypometabolic convergence index [J].

Chen, Kewei ;

Ayutyanont, Napatkamon ;

Langbaum, Jessica B. S. ;

Fleisher, Adam S. ;

Reschke, Cole ;

Lee, Wendy ;

Liu, Xiaofen ;

Bandy, Dan ;

Alexander, Gene E. ;

Thompson, Paul M. ;

Shaw, Leslie ;

Trojanowski, John Q. ;

Jack, Clifford R., Jr. ;

Landau, Susan M. ;

Foster, Norman L. ;

Harvey, Danielle J. ;

Weiner, Michael W. ;

Koeppe, Robert A. ;

Jagust, William J. ;

Reiman, Eric M. .

NEUROIMAGE, 2011, 56 (01) :52-60

[7] Comparing Hippocampal Atrophy in Alzheimer's Dementia and Dementia with Lewy Bodies [J].

Chow, Nicole ;

Aarsland, Dag ;

Honarpisheh, Hedieh ;

Beyer, Mona K. ;

Somme, Johanne H. ;

Elashoff, David ;

Rongve, Arvid ;

Tysnes, Ole B. ;

Thompson, Paul M. ;

Apostolova, Liana G. .

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2012, 34 (01) :44-50

[8]

Chu LW, 2012, HONG KONG MED J, V18, P228

[9] Hippocampal and entorhinal atrophy in mild cognitive impairment - Prediction of Alzheimer disease [J].

Devanand, D. P. ;

Pradhaban, G. ;

Liu, X. ;

Khandji, A. ;

De Santi, S. ;

Segal, S. ;

Rusinek, H. ;

Pelton, G. H. ;

Honig, L. S. ;

Mayeux, R. ;

Stern, Y. ;

Tabert, M. H. ;

de Leon, M. J. .

NEUROLOGY, 2007, 68 (11) :828-836

[10] Revising the definition of Alzheimer's disease: a new lexicon [J].

Dubois, Bruno ;

Feldman, Howard H. ;

Jacova, Claudia ;

Cummings, Jeffrey L. ;

DeKosky, Steven T. ;

Barberger-Gateau, Pascale ;

Delacourte, Andre ;

Frisoni, Giovanni ;

Fox, Nick C. ;

Galasko, Douglas ;

Gauthier, Serge ;

Hampel, Harald ;

Jicha, Gregory A. ;

Meguro, Kenichi ;

O'Brien, John ;

Pasquier, Florence ;

Robert, Philippe ;

Rossor, Martin ;

Salloway, Steven ;

Sarazin, Marie ;

de Souza, Leonardo C. ;

Stern, Yaakov ;

Visser, Pieter J. ;

Scheltens, Philip .

LANCET NEUROLOGY, 2010, 9 (11) :1118-1127

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