Clinicopathological differences in signet ring cell adenocarcinoma between early and advanced gastric cancer

被引：68
作者：
Kao, Yi-Chu [1 ,2 ]
Fang, Wen-Liang [1 ,2 ]
Wang, Ruei-Fang [3 ]
Li, Anna Fen-Yau [2 ,4 ]
Yang, Muh-Hwa [5 ,6 ]
Wu, Chew-Wun [1 ,2 ]
Shyr, Yi-Ming [1 ,2 ]
Huang, Kuo-Hung [1 ,5 ]
机构：
[1] Taipei Vet Gen Hosp, Dept Surg, Div Gen Surg, 201,Sect 2,Shipai Rd, Taipei 11217, Taiwan
[2] Natl Yang Ming Univ, Sch Med, Taipei, Taiwan
[3] Taipei City Hosp, Ren Ai Branch, Dept Emergency Med, Taipei, Taiwan
[4] Taipei Vet Gen Hosp, Dept Pathol, Taipei, Taiwan
[5] Natl Yang Ming Univ, Inst Clin Med, Sch Med, Taipei, Taiwan
[6] Taipei Vet Gen Hosp, Div Med Oncol, Dept Oncol, Taipei, Taiwan
来源：
GASTRIC CANCER | 2019年 / 22卷 / 02期
关键词：
Gastric cancer; Gastrectomy; Signet ring cell adenocarcinoma; CARCINOMA; PROGNOSIS; HISTOLOGY; IMPACT; CHEMOTHERAPY; DISSECTION; RESECTION;
D O I：
10.1007/s10120-018-0860-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
BackgroundSignet ring cell adenocarcinoma is a histological classification based on the WHO classification. The presence of this specific histological type is associated with a worse pathological appearance. The prognosis of signet ring cell adenocarcinoma in gastric cancer patients after curative surgery is still under debate.MethodsFrom January 1988 to December 2012, a total of 2971 patients, including 819 early and 2152 advanced gastric cancer patients underwent curative resection for gastric cancer. Among them, there were 185 cases of signet ring cell adenocarcinoma in early gastric cancer patients, while there were 570 cases in advanced gastric cancer patients.ResultsThe overall incidence of signet ring cell adenocarcinoma was 25.4%. Our results showed that the 5-year overall survival rates of early gastric cancer patients with signet ring cell adenocarcinoma and non-signet ring cell adenocarcinoma were 90.7 and 83.2%, respectively (P=0.001). The 5-year disease-free survival rates of early gastric cancer patients with signet ring cell adenocarcinoma and non-signet ring cell adenocarcinoma were 87.4 and 81.6%, respectively (P=0.003). The 5-year overall survival rates of advanced gastric cancer patients with signet ring cell adenocarcinoma and non-signet ring cell adenocarcinoma were 32.1 and 37.9%, respectively (P=0.041). The 5-year disease-free survival rates of advanced gastric cancer patients with signet ring cell adenocarcinoma and non-signet ring cell adenocarcinoma were 28.6 and 35.2%, respectively (P=0.037). Signet ring cell adenocarcinoma was an independent predictor for overall survival in advanced gastric cancer (P=0.017).ConclusionThe clinical features and prognosis of signet ring cell adenocarcinoma are different between early and advanced gastric cancer. Signet ring cell adenocarcinoma is a poor prognostic factor in advanced gastric cancer after curative resection.
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页码：255 / 263
页数：9
相关论文
共 28 条
  • [1] [Anonymous], 1998, GASTRIC CANCER, DOI DOI 10.1007/PL00011681
  • [2] [Anonymous], 1990, WHO INT HIST CLASS T
  • [3] [Anonymous], 2017, AJCC CANC STAGING MA
  • [4] Stage-Stratified Prognosis of Signet Ring Cell Histology in Patients Undergoing Curative Resection for Gastric Adenocarcinoma
    Bamboat, Zubin M.
    Tang, Laura H.
    Vinuela, Eduardo
    Kuk, Deborah
    Gonen, Mithat
    Shah, Manish A.
    Brennan, Murray F.
    Coit, Daniel G.
    Strong, Vivian E.
    [J]. ANNALS OF SURGICAL ONCOLOGY, 2014, 21 (05) : 1678 - 1685
  • [5] Differential Prognostic Implications of Gastric Signet Ring Cell Carcinoma Stage Adjusted Analysis From a Single High-volume Center in Asia
    Chon, Hong Jae
    Hyung, Woo Jin
    Kim, Chan
    Park, Sohee
    Kim, Jie-Hyun
    Park, Chan Hyuk
    Ahn, Joong Bae
    Kim, Hyunki
    Chung, Hyun Cheol
    Rha, Sun Young
    Noh, Sung Hoon
    Jeung, Hei-Cheul
    [J]. ANNALS OF SURGERY, 2017, 265 (05) : 946 - 953
  • [6] Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
    Ferlay, Jacques
    Soerjomataram, Isabelle
    Dikshit, Rajesh
    Eser, Sultan
    Mathers, Colin
    Rebelo, Marise
    Parkin, Donald Maxwell
    Forman, David
    Bray, Freddie
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2015, 136 (05) : E359 - E386
  • [7] Is the negative prognostic impact of signet ring cell histology maintained in early gastric adenocarcinoma?
    Gronnier, Caroline
    Messager, Mathieu
    Robb, William B.
    Thiebot, Timothee
    Louis, Damien
    Luc, Guillaume
    Piessen, Guillaume
    Mariette, Christophe
    [J]. SURGERY, 2013, 154 (05) : 1093 - 1099
  • [8] Indication for endoscopic mucosal resection in early signet ring cell gastric cancer
    Ha, T. K.
    An, J. Y.
    Youn, H. K.
    Noh, J. H.
    Sohn, T. S.
    Kim, S.
    [J]. ANNALS OF SURGICAL ONCOLOGY, 2008, 15 (02) : 508 - 513
  • [9] Is Preoperative Chemotherapy Followed by Surgery the Appropriate Treatment for Signet Ring Cell Containing Adenocarcinomas of the Esophagogastric Junction and Stomach?
    Heger, Ulrike
    Blank, Susanne
    Wiecha, Christiane
    Langer, Rupert
    Weichert, Wilko
    Lordick, Florian
    Bruckner, Thomas
    Dobritz, Martin
    Burian, Maria
    Springfeld, Christoph
    Grenacher, Lars
    Siewert, Joerg-Ruediger
    Buchler, Markus
    Ott, Katja
    [J]. ANNALS OF SURGICAL ONCOLOGY, 2014, 21 (05) : 1739 - 1748
  • [10] Early gastric carcinoma with signet ring cell histology
    Hyung, WJ
    Noh, SH
    Lee, JH
    Huh, JJ
    Lah, KH
    Choi, SH
    Min, JS
    [J]. CANCER, 2002, 94 (01) : 78 - 83
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