Biochemical and functional interactions between HIV-1 Tat protein and TAR RNA

被引：166
|
作者：
Rana, TM
Jeang, KT
机构：
[1] Robert Wood Johnson Rutgers Med Sch, Dept Pharmacol, Piscataway, NJ 08854 USA
[2] NIH, Mol Microbiol Lab, Bethesda, MD 20892 USA
来源：
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 1999年 / 365卷 / 02期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1006/abbi.1999.1206
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
HIV-1 trans-activator of transcription (Tat) is an unusual transcriptional activator in being an RNA-binding protein rather than a DNA-binding protein. Recent findings have greatly advanced our understanding of the transcriptional function(s) of this protein. Here we review how Tat interacts with trans-activation responsive RNA and how this interaction contributes to transcription. We discuss the biological implications of recent studies showing an association of Tat with cellular kinases(s) and protein acetylases. Evidence for nontranscriptional activities of the Tat protein is also summarized. (C) 1999 Academic Press.
引用
收藏
页码：175 / 185
页数：11
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