Acute Gastrointestinal Infection Induces Long-Lived Microbiota-Specific T Cell Responses

被引：300

作者：

Hand, Timothy W. ^{[1
]}

Dos Santos, Liliane M. ^{[1
,2
]}

Bouladoux, Nicolas ^{[1
]}

Molloy, Michael J. ^{[1
]}

Pagan, Antonio J. ^{[3
]}

Pepper, Marion ^{[3
,4
]}

Maynard, Craig L. ^{[5
]}

Elson, Charles O., III ^{[6
]}

Belkaid, Yasmine ^{[1
]}

机构：

[1] NIAID, Mucosal Immun Sect, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA

[2] Univ Fed Minas Gerais, Lab Gnotobiol & Immunol, BR-31270901 Belo Horizonte, MG, Brazil

[3] Univ Minnesota, Microbiol Immunol & Canc Biol Program, Minneapolis, MN 55455 USA

[4] Univ Washington, Dept Immunol, Seattle, WA 98195 USA

[5] Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA

[6] Univ Alabama Birmingham, Mucosal HIV & Immunobiol Ctr, Birmingham, AL 35294 USA

来源：

SCIENCE | 2012年 / 337卷 / 6101期

关键词：

GUT COMMENSAL BACTERIA; TOXOPLASMA-GONDII; CROHNS-DISEASE; INDUCTION; DOMINANT; EFFECTOR; IMMUNITY; NAIVE; IGA;

D O I：

10.1126/science.1220961

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The mammalian gastrointestinal tract contains a large and diverse population of commensal bacteria and is also one of the primary sites of exposure to pathogens. How the immune system perceives commensals in the context of mucosal infection is unclear. Here, we show that during a gastrointestinal infection, tolerance to commensals is lost, and microbiota-specific T cells are activated and differentiate to inflammatory effector cells. Furthermore, these T cells go on to form memory cells that are phenotypically and functionally consistent with pathogen-specific T cells. Our results suggest that during a gastrointestinal infection, the immune response to commensals parallels the immune response against pathogenic microbes and that adaptive responses against commensals are an integral component of mucosal immunity.

引用

页码：1553 / 1556

页数：4

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