Characterization of a novel polymeric prodrug of an antibacterial agent synthesized by mechanochemical solid-state polymerization

被引：3
作者：
Yamauchi, Yukinori [1 ]
Doi, Naoki [2 ]
Kondo, Shin-ichi [2 ]
Sasai, Yasushi [2 ]
Kuzuya, Masayuki [3 ]
机构：
[1] Matsuyama Univ, Dept Pharmaceut Phys Chem, Coll Pharmaceut Sci, 4-2 Bunkyo Cho, Matsuyama, Ehime 7908578, Japan
[2] Gifu Pharmaceut Univ, Dept Drug Delivery Technol & Sci, Lab Pharmaceut Phys Chem, Gifu, Japan
[3] Chubu Gakuin Univ, Fac Human Welf, Dept Hlth & Welf, Gifu, Japan
来源：
DRUG DEVELOPMENT RESEARCH | 2020年 / 81卷 / 07期
关键词：
acid anhydride bond; antibacterial agent; controlled release; mechanochemical polymerization; polymeric prodrug; ANTIINFLAMMATORY DRUGS NSAIDS; PHARMACOLOGICAL-ACTIVITY; HYDROLYTIC DEGRADATION; RELEASE; COPOLYMERS; STABILITY; ESTERS; ACID);
D O I：
10.1002/ddr.21700
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Polycrystalline methacryloyl monomers of the antibacterial drug nalidixic acid with an anhydride bond to the drug carboxyl group were prepared. The physicochemical properties of the synthesized vinyl monomer were characterized using X-ray powder diffraction, thermal analysis, and polarized light microscopy measurements. Mechanochemical solid-state polymerization of the resulting monomers was carried out to yield a novel polymeric prodrug. The in vitro hydrolysis behavior of the polymeric prodrug indicated that the release rate of drug from the polymeric prodrug was clearly dependent on the pH value of the hydrolysis solution. Moreover, sustained release of the drug at an almost constant rate for more than 10 hr was shown in both neutral and alkaline solutions. The results suggest that anhydride-based polymeric prodrugs could be potentially useful in colon targeted drug delivery systems.
引用
收藏
页码：867 / 874
页数：8
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