Photochemical Internalization: A New Tool for Gene and Oligonucleotide Delivery

被引：26

作者：

Berg, Kristian ^{[1
]}

Berstad, Maria ^{[1
]}

Prasmickaite, Lina ^{[1
]}

Weyergang, Anette ^{[1
]}

Selbo, Pal K. ^{[1
]}

Hedfors, Ida ^{[1
]}

Hogset, Anders ^{[2
]}

机构：

[1] Oslo Univ Hosp, Dept Radiat Biol, Norwegian Radium Hosp, N-0310 Oslo, Norway

[2] PCI Biotech AS, N-0375 Oslo, Norway

来源：

NUCLEIC ACID TRANSFECTION | 2010年 / 296卷

关键词：

Drug delivery; Gene therapy; Macromolecule; Peptide nucleic acid; Photochemical internalization; Photodynamic; Photosensitizer; Protein toxin; siRNA; SULFONATED ALUMINUM PHTHALOCYANINES; ENHANCED ADENOVIRAL TRANSDUCTION; PHOTODYNAMIC-THERAPY; TRANSGENE EXPRESSION; DRUG-DELIVERY; CELLULAR DELIVERY; IN-VITRO; CYTOSOLIC DELIVERY; P53-MUTATED HEAD; ENDOSOMAL ESCAPE;

D O I：

10.1007/128_2010_63

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Photochemical internalization (PCI) is a novel technology for release of endocytosed macromolecules into the cytosol. The technology is based on the use of photosensitizers located in endocytic vesicles. Upon activation by light such photosensitizers induce a release of macromolecules from their compartmentalization in endocytic vesicles. PCI has been shown to increase the biological activity of a large variety of macromolecules and other molecules that do not readily penetrate the plasma membrane, including type I ribosome-inactivating proteins, immunotoxins, plasmids, adenovirus, various oligonucleotides, dendrimer-based delivery of chemotherapeutica and unconjugated chemotherapeutica such as bleomycin and doxorubicin. This review will present the basis for the PCI concept and the most recent significant developments.

引用

页码：251 / 281

页数：31

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