Influence of an anti-metastatic ruthenium(III) prodrug on extracellular protein-protein interactions: studies by bio-layer interferometry

被引：23

作者：

Levina, Aviva ^{[1
]}

Lay, Peter A. ^{[1
]}

机构：

[1] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia

来源：

INORGANIC CHEMISTRY FRONTIERS | 2014年 / 1卷 / 01期

基金：

澳大利亚研究理事会;

关键词：

TRANSFERRIN RECEPTOR; BINDING; IRON; COMPLEXES; PH;

D O I：

10.1039/c3qi00054k

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

In the first application of bio-layer interferometry in medicinal inorganic chemistry, Fe(III)-transferrin (Tf) binds strongly to Tf receptor 1 (TfR1), but an apo-Tf adduct of the anti-metastatic prodrug, NAMI-A does not bind specifically to TfR1. Binding of NAMI-A to albumin affects its interactions with other blood proteins, such as immunoglobulins.

引用

收藏

页码：44 / 48

页数：5

相关论文

共 23 条

[1]

AISEN P, 1967, J BIOL CHEM, V242, P2484

[2]

[Anonymous], 2013, 14 FORTEBIO

[3] Approaching tumour therapy beyond platinum drugs Status of the art and perspectives of ruthenium drug candidates [J].

Bergamo, A. ;

Gaiddon, C. ;

Schellens, J. H. M. ;

Beijnen, J. H. ;

Sava, G. .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2012, 106 (01) :90-99

[4] PH AND THE RECYCLING OF TRANSFERRIN DURING RECEPTOR-MEDIATED ENDOCYTOSIS [J].

DAUTRYVARSAT, A ;

CIECHANOVER, A ;

LODISH, HF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (08) :2258-2262

[5]

El Hage Chanme J.-M., 2012, BIOCHIM BIOPHYS ACTA, V1820, P334

[6] Lodination significantly influences the binding of human transferrin to the transferrin receptor [J].

Fuchs, H ;

Gessner, R .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2002, 1570 (01) :19-26

[7] Protein microarrays, biosensors, and cell-based methods for secretome-wide extracellular protein-protein interaction mapping [J].

Gonzalez, Lino C. .

METHODS, 2012, 57 (04) :448-458

[8] Transferrin Serves As a Mediator to Deliver Organometallic Ruthenium(II) Anticancer Complexes into Cells [J].

Guo, Wei ;

Zheng, Wei ;

Luo, Qun ;

Li, Xianchan ;

Zhao, Yao ;

Xiong, Shaoxiang ;

Wang, Fuyi .

INORGANIC CHEMISTRY, 2013, 52 (09) :5328-5338

[9] Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor [J].

Lebrón, JA ;

Bennett, MJ ;

Vaughn, DE ;

Chirino, AJ ;

Snow, PM ;

Mintier, GA ;

Feder, JN ;

Bjorkman, PJ .

CELL, 1998, 93 (01) :111-123

[10] Biotransformations of Anticancer Ruthenium(III) Complexes: An X-Ray Absorption Spectroscopic Study [J].

Levina, Aviva ;

Aitken, Jade B. ;

Gwee, Yee Yen ;

Lim, Zhi Jun ;

Liu, Mimi ;

Singharay, Anannya Mitra ;

Wong, Pok Fai ;

Lay, Peter A. .

CHEMISTRY-A EUROPEAN JOURNAL, 2013, 19 (11) :3609-3619