Influence of an anti-metastatic ruthenium(III) prodrug on extracellular protein-protein interactions: studies by bio-layer interferometry

被引：23
作者：
Levina, Aviva [1 ]
Lay, Peter A. [1 ]
机构：
[1] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia
来源：
INORGANIC CHEMISTRY FRONTIERS | 2014年 / 1卷 / 01期
基金：
澳大利亚研究理事会;
关键词：
TRANSFERRIN RECEPTOR; BINDING; IRON; COMPLEXES; PH;
D O I：
10.1039/c3qi00054k
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
In the first application of bio-layer interferometry in medicinal inorganic chemistry, Fe(III)-transferrin (Tf) binds strongly to Tf receptor 1 (TfR1), but an apo-Tf adduct of the anti-metastatic prodrug, NAMI-A does not bind specifically to TfR1. Binding of NAMI-A to albumin affects its interactions with other blood proteins, such as immunoglobulins.
引用
收藏
页码：44 / 48
页数：5
相关论文
共 23 条
  • [1] AISEN P, 1967, J BIOL CHEM, V242, P2484
  • [2] [Anonymous], 2013, 14 FORTEBIO
  • [3] Approaching tumour therapy beyond platinum drugs Status of the art and perspectives of ruthenium drug candidates
    Bergamo, A.
    Gaiddon, C.
    Schellens, J. H. M.
    Beijnen, J. H.
    Sava, G.
    [J]. JOURNAL OF INORGANIC BIOCHEMISTRY, 2012, 106 (01) : 90 - 99
  • [4] PH AND THE RECYCLING OF TRANSFERRIN DURING RECEPTOR-MEDIATED ENDOCYTOSIS
    DAUTRYVARSAT, A
    CIECHANOVER, A
    LODISH, HF
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (08): : 2258 - 2262
  • [5] El Hage Chanme J.-M., 2012, BIOCHIM BIOPHYS ACTA, V1820, P334
  • [6] Lodination significantly influences the binding of human transferrin to the transferrin receptor
    Fuchs, H
    Gessner, R
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2002, 1570 (01): : 19 - 26
  • [7] Protein microarrays, biosensors, and cell-based methods for secretome-wide extracellular protein-protein interaction mapping
    Gonzalez, Lino C.
    [J]. METHODS, 2012, 57 (04) : 448 - 458
  • [8] Transferrin Serves As a Mediator to Deliver Organometallic Ruthenium(II) Anticancer Complexes into Cells
    Guo, Wei
    Zheng, Wei
    Luo, Qun
    Li, Xianchan
    Zhao, Yao
    Xiong, Shaoxiang
    Wang, Fuyi
    [J]. INORGANIC CHEMISTRY, 2013, 52 (09) : 5328 - 5338
  • [9] Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor
    Lebrón, JA
    Bennett, MJ
    Vaughn, DE
    Chirino, AJ
    Snow, PM
    Mintier, GA
    Feder, JN
    Bjorkman, PJ
    [J]. CELL, 1998, 93 (01) : 111 - 123
  • [10] Biotransformations of Anticancer Ruthenium(III) Complexes: An X-Ray Absorption Spectroscopic Study
    Levina, Aviva
    Aitken, Jade B.
    Gwee, Yee Yen
    Lim, Zhi Jun
    Liu, Mimi
    Singharay, Anannya Mitra
    Wong, Pok Fai
    Lay, Peter A.
    [J]. CHEMISTRY-A EUROPEAN JOURNAL, 2013, 19 (11) : 3609 - 3619
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