Studies on Anticancer Activities of Lactoferrin and Lactoferricin

被引：34

作者：

Yin, Cui Ming ^{[1
]}

Wong, Jack Ho ^{[1
]}

Xia, Jiang ^{[2
]}

Ng, Tzi Bun ^{[1
]}

机构：

[1] Chinese Univ Hong Kong, Sch Biomed Sci, Fac Med, Hong Kong, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, Dept Chem, Fac Med, Hong Kong, Hong Kong, Peoples R China

来源：

CURRENT PROTEIN & PEPTIDE SCIENCE | 2013年 / 14卷 / 06期

关键词：

Application; cancer; delta lactoferrin; lactoferrin; lactoferricin; mechanism; talactoferrin; drug delivery; ADMINISTERED BOVINE LACTOFERRIN; CYCLIN-DEPENDENT KINASES; BLACK TEA POLYPHENOLS; ANTI-HSV ACTIVITY; CANCER CELL-LINE; ANTIMICROBIAL PEPTIDE; MILK LACTOFERRIN; HEPARAN-SULFATE; BINDING PROTEIN; IN-VITRO;

D O I：

10.2174/13892037113149990066

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review mainly summarizes results of recent studies on the anticancer activity of the multifunctional protein lactoferrin (Lf) and its derived peptide lactoferricin (Lfcin). The basic information on Lf and Lfcin, such as their sources, structures, and biological properties which favor their antitumor activity is introduced. The major anticancer mechanisms of Lf and Lfcin including cell cycle arrest, apoptosis, anti-angiogenesis, antimetastasis, immune modulation and necrosis are discussed. Other information from in vivo studies employing a mouse model is also provided. In addition, the roles of talatoferrin and delta lactoferrin, as well as improvement in drug delivery will be covered.

引用

页码：492 / 503

页数：12

共 116 条

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