Comparison of Fibroblast and Osteoblast Response to Cultivation on Titanium Implants with Different Grain Sizes

被引：12

作者：

Babuska, Vaclav ^{[1
]}

Dobra, Jana ^{[1
]}

Kulda, Vlastimil ^{[1
]}

Kripnerova, Michaela ^{[2
]}

Moztarzadeh, Amin ^{[1
]}

Bolek, Lukas ^{[3
]}

Lahoda, Jiri ^{[4
]}

Hrusak, Daniel ^{[5
,6
]}

机构：

[1] Charles Univ Prague, Dept Med Chem & Biochem, Fac Med Pilsen, Plzen 30166, Czech Republic

[2] Charles Univ Prague, Dept Biol, Fac Med Pilsen, Plzen 32300, Czech Republic

[3] Charles Univ Prague, Biomed Ctr, Fac Med Pilsen, Plzen 32300, Czech Republic

[4] Univ W Bohemia, Dept Appl Elect & Telecommun, Fac Elect Engn, Plzen 30614, Czech Republic

[5] Univ Hosp, Dept Stomatol, Fac Med Pilsen, Plzen 30100, Czech Republic

[6] Charles Univ Prague, Plzen 30100, Czech Republic

来源：

JOURNAL OF NANOMATERIALS | 2015年 / 2015卷

关键词：

MESENCHYMAL STEM-CELLS; NANOSTRUCTURED TITANIUM; PLASTIC-DEFORMATION; BIOCOMPATIBILITY; ADHESION; POWDER; FABRICATION; SURFACES; TISSUE; ALLOY;

D O I：

10.1155/2015/920893

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The in vitro response of human fibroblast cell line HFL1 and human osteoblast cell line hFOB 1.19 on nanostructured titanium with different grain sizes has been compared in the present study. Used samples of titanium produced by equal channel angular (ECA) pressing have grain sizes of 160 nm, 280 nm, and 2400 nm with cross-and longitudinal sections. Similar cellular behaviour was observed on all studied biomaterials. There were significant differences related to the initial phase of attachment, but not in proliferation. Furthermore, the results indicate that osteoblasts grow best on material with grain size of 160 nm with a longitudinal section in comparison with other examined materials. Therefore, this material could be recommended for further evaluation with respect to osseointegration in vivo.

引用

页数：9

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