Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) study

被引：22

作者：

Maple-Brown, Louise J. ^{[1
,2
]}

Brown, Alex ^{[3
,4
]}

Lee, I-Lynn ^{[1
]}

Connors, Christine ^{[5
]}

Oats, Jeremy ^{[5
,6
]}

McIntyre, Harold D. ^{[7
]}

Whitbread, Cherie ^{[1
,2
]}

Moore, Elizabeth ^{[8
]}

Longmore, Danielle ^{[1
]}

Dent, Glynis ^{[9
]}

Corpus, Sumaria ^{[2
]}

Kirkwood, Marie ^{[1
]}

Svenson, Stacey ^{[10
]}

van Dokkum, Paula ^{[9
,10
]}

Chitturi, Sridhar ^{[2
]}

Thomas, Sujatha ^{[11
]}

Eades, Sandra ^{[12
]}

Stone, Monique ^{[13
]}

Harris, Mark ^{[14
]}

Inglis, Chrissie ^{[15
]}

Dempsey, Karen ^{[5
]}

Dowden, Michelle ^{[16
]}

Lynch, Michael ^{[17
]}

Boyle, Jacqueline ^{[1
,18
]}

Sayers, Sue ^{[1
]}

Shaw, Jonathan ^{[19
]}

Zimmet, Paul ^{[19
]}

O'Dea, Kerin ^{[4
]}

机构：

[1] Charles Darwin Univ, Menzies Sch Hlth Res, Darwin, NT 0811, Australia

[2] Royal Darwin Hosp, Div Med, Darwin, NT, Australia

[3] South Australian Hlth & Med Res Inst, Adelaide, SA, Australia

[4] Univ S Australia, Sch Populat Hlth, Adelaide, SA 5001, Australia

[5] Northern Terr Dept Hlth, Darwin, NT, Australia

[6] Univ Melbourne, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia

[7] Univ Queensland, Mater Res Inst, Brisbane, Qld, Australia

[8] Aboriginal Med Serv Alliance Northern Terr, Darwin, NT, Australia

[9] Alice Springs Hosp, Alice Springs, NT, Australia

[10] Baker IDI Heart & Diabet Inst, Central Australia, Australia

[11] Royal Darwin Hosp, Dept Obstet & Gynaecol, Darwin, NT, Australia

[12] Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, Australia

[13] Royal Darwin Hosp, Dept Pediat, Darwin, NT, Australia

[14] Mater Childrens Hosp, South Brisbane, Qld, Australia

[15] Hlth Living NT, Darwin, NT, Australia

[16] Aboriginal Hlth Council West Australia, Perth, WA, Australia

[17] Top End Hlth & Hosp Serv, Pathol Network, Darwin, NT, Australia

[18] Monash Univ, Sch Publ Hlth & Prevent Med, Monash Ctr Hlth Res & Implementat, Melbourne, Vic 3004, Australia

[19] Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia

来源：

BMC PREGNANCY AND CHILDBIRTH | 2013年 / 13卷

基金：

英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

Diabetes in pregnancy; Gestational diabetes; Antenatal care; Birth weight; Neonatal body composition; Anthropometry; Indigenous Australian; Aboriginal; MELLITUS; TYPE-2; WOMEN; HYPERGLYCEMIA; OBESITY; EXPOSURE; RISKS; HAPO;

D O I：

10.1186/1471-2393-13-221

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Background: Diabetes in pregnancy carries an increased risk of adverse pregnancy outcomes for both the mother and foetus, but it also provides an excellent early opportunity for intervention in the life course for both mother and baby. In the context of the escalating epidemic of chronic diseases among Indigenous Australians, it is vital that this risk is reduced as early as possible in the life course of the individual. The aims of the PANDORA Study are to: (i) accurately assess rates of diabetes in pregnancy in the Northern Territory (NT) of Australia, where 38% of babies are born to Indigenous mothers; (ii) assess demographic, clinical, biochemical, anthropometric, socioeconomic and early life development factors that may contribute to key maternal and neonatal birth outcomes associated with diabetes in pregnancy; and (iii) monitor relevant post-partum clinical outcomes for both the mothers and their babies. Methods/Design: Eligible participants are all NT women with diabetes in pregnancy aged 16 years and over. Information collected includes: standard antenatal clinical information, diagnosis and management of diabetes in pregnancy, socio-economic status, standard clinical birth information (delivery, gestational age, birth weight, adverse antenatal and birth outcomes). Cord blood is collected at the time of delivery and detailed neonatal anthropometric measurements performed within 72 hours of birth. Information will also be collected regarding maternal postpartum glucose tolerance and cardio-metabolic risk factor status, breastfeeding and growth of the baby up to 2 years post-partum in the first instance. Discussion: This study will accurately document rates and outcomes of diabetes in pregnancy in the NT of Australia, including the high-risk Indigenous Australian population. The results of this study should contribute to policy and clinical guidelines with the goal of reducing the future risk of obesity and diabetes in both mothers and their offspring.

引用

页数：8

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