Selective C-F Bond Activation: Substitution of Unactivated Alkyl Fluorides using YbI3

被引：51

作者：

Traff, Annika M. ^{[1
]}

Janjetovic, Mario ^{[1
]}

Ta, Linda ^{[1
]}

Hilmersson, Goran ^{[1
]}

机构：

[1] Univ Gothenburg, Dept Chem & Mol Biol, SE-41296 Gothenburg, Sweden

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 46期

基金：

瑞典研究理事会;

关键词：

chemoselectivity; fluorine; iodine; synthetic methods; ytterbium; PALLADIUM-CATALYZED SUBSTITUTION; ORGANOFLUORINE CHEMISTRY; MAGNESIUM REAGENTS; CLEAVAGE REACTIONS; C(SP(3))-F BONDS; DIFLUOROMETHYLATION; LANTHANIDE; CONVERSION;

D O I：

10.1002/anie.201306104

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

F makes the break: The carbon-fluorine single bond is quite strong, thus making aliphatic C-F bond scission unusually challenging. A new methodology utilizing YbI3 leads to the conversion of a C-F bond into a C-I bond, and is compatible with various functional groups. The reaction is exceptionally selective towards alkyl fluorides and proceeds under mild conditions. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：12073 / 12076

页数：4

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