Fast Synthesis of Complex Enantiopure Heterocyclic Scaffolds by a Tandem Sequence of Simple Transformations on α-Hydroxyaldehydes

被引：27

作者：

Cannillo, Alexandre ^{[1
]}

Norsikian, Stephanie ^{[1
]}

Retailleau, Pascal ^{[1
]}

Dau, Marie-Elise Tran Huu ^{[1
]}

Iorga, Bogdan I. ^{[1
]}

Beau, Jean-Marie ^{[1
,2
,3
]}

机构：

[1] CNRS, Inst Chim Subst Nat, UPR 2301, Ctr Rech Gif, F-91198 Gif Sur Yvette, France

[2] Univ Paris 11, F-91405 Orsay, France

[3] CNRS, Inst Chim Mol & Mat Orsay, Lab Synth Biomol, F-91405 Orsay, France

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2013年 / 19卷 / 28期

关键词：

borono Mannich; carbohydrates; cross metathesis; Diels-Alder reactions; tandem reaction; BORONO-MANNICH REACTION; ASYMMETRIC-SYNTHESIS; ORGANOBORONIC ACIDS; ORGANIC-SYNTHESIS; CONCISE SYNTHESIS; DOMINO REACTIONS; FORMAL SYNTHESIS; DIELS; ALCOHOLS; AMINES;

D O I：

10.1002/chem.201301712

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two tandems are faster than one! Properly sequenced reactions initiated by the Petasis aminoalcohol synthesis from boronic acids, diallylamine, and α-hydroxyaldehydes, including free aldoses, leads to rapid construction of complex enantiopure structures (see scheme). Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：9127 / 9131

页数：5

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