Large-scale analysis of the human and mouse transcriptomes

被引:1224
|
作者
Su, AI
Cooke, MP
Ching, KA
Hakak, Y
Walker, JR
Wiltshire, T
Orth, AP
Vega, RG
Sapinoso, LM
Moqrich, A
Patapoutian, A
Hampton, GM
Schultz, PG
Hogenesch, JB
机构
[1] Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
[2] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
[3] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA
关键词
D O I
10.1073/pnas.012025199
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
High-throughput gene expression profiling has become an important tool for investigating transcriptional activity in a variety of biological samples. To date, the vast majority of these experiments have focused on specific biological processes and perturbations. Here, we have generated and analyzed gene expression from a set of samples spanning a broad range of biological conditions. Specifically, we profiled gene expression from 91 human and mouse samples across a diverse array of tissues, organs, and cell lines. Because these samples predominantly come from the normal physiological state in the human and mouse, this dataset represents a preliminary, but substantial, description of the normal mammalian transcriptome. We have used this dataset to illustrate methods of mining these data, and to reveal insights into molecular and physiological gene function, mechanisms of transcriptional regulation, disease etiology, and comparative genomics. Finally, to allow the scientific community to use this resource, we have built a free and publicly accessible website (http:/ / expression.gnf.org) that integrates data visualization and curation of current gene annotations.
引用
收藏
页码:4465 / 4470
页数:6
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