A novel Fe-hemin-metal organic frameworks supported on chitosan-reduced graphene oxide for real-time monitoring of H2O2 released from living cells

被引：30
|
作者：
Zhao, Peng [1 ]
Chen, Sha [1 ]
Zhou, Jun [2 ]
Zhang, Suyi [2 ]
Huo, Danqun [1 ]
Hou, Changjun [1 ,3 ]
机构：
[1] Chongqing Univ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing 400044, Peoples R China
[2] Sichuan Univ Sci & Engn, Coll Bioengn, Liquor Making Biol Technol & Applicat Key Lab Sic, Zigong 643000, Peoples R China
[3] Chongqing Univ, Sch Microelect & Commun Engn, Chongqing Key Lab Biopercept & Intelligent Inform, Chongqing 400044, Peoples R China
来源：
ANALYTICA CHIMICA ACTA | 2020年 / 1128卷
基金：
中国国家自然科学基金;
关键词：
Fe-hemin-Metal organic frameworks; Electrochemical sensor; Hydrogen peroxide; Living cells; HYDROGEN-PEROXIDE; ELECTROCHEMICAL DETECTION; QUADRUPLEX DNAZYME; SENSING PLATFORM; OXIDATIVE BURST; OILSEED RAPE; CARBON; SENSOR; NANOCOMPOSITES; PERFORMANCE;
D O I：
10.1016/j.aca.2020.06.008
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Herein, a kind of novel hemin-based metal organic frameworks (Fe-hemin-MOFs) with unique peroxidase-like bioactivity was developed for the first time. The synthesized Fe-hemin-MOFs exhibited satisfactory catalytic activity toward hydrogen peroxide (H2O2). When it was further supported on Chitosan-reduced graphene oxide (CS-rGO), amplified electrochemical signal could be obtained. The Fe-hemin-MOFs/CS-rGO composite was used to construct a novel H2O2 electrochemical sensor. The elec-trocatalytic reduction of H2O2 displayed two segments linearity range from 1 to 61 mM and 61-1311 mM, as well as a low detection limit of 0.57 mM. Furthermore, the proposed sensor was successfully used for real-time monitoring of H2O2 released from living cells, which extended the practical application of MOFs-based sensors in monitoring the pathological process in living cells. (C) 2020 Elsevier B.V. All rights reserved.
引用
收藏
页码：90 / 98
页数：9
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