Synthesis and antimicrobial activity of imidazole and pyridine appended cholestane-based conjugates

被引：39

作者：

Kim, Hong-Seok ^{[1
]}

Jadhav, Jyoti R. ^{[1
]}

Jung, Sung-Ji ^{[2
]}

Kwak, Jin-Hwan ^{[2
]}

机构：

[1] Kyungpook Natl Univ, Dept Appl Chem, Taegu 702701, South Korea

[2] Handong Global Univ, Sch Life Sci, Pohang 791708, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 15期

关键词：

Cholestane; Imidazole; Pyridine; Antimicrobial activity; RESISTANT STAPHYLOCOCCUS-AUREUS; ANTIINFLAMMATORY ACTIVITIES; DERIVATIVES; SQUALAMINE; DESIGN; ANTIBIOTICS; ANTIFUNGAL; PEPTIDES; BACTERIA; AGENTS;

D O I：

10.1016/j.bmcl.2013.05.098

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 3 alpha-amino-5 alpha-cholestane and 3 alpha,7 alpha-diamino-5 alpha-cholestane derivatives containing imidazole and pyridine rings were synthesized by simple and effective reductive amination, and their in vitro activities against a range of Gram-positive and Gram-negative strains were evaluated. Most of the compound exhibited enhanced activity against MRSA pathogen. 3 alpha,7 alpha-Di(pyridylmethyl)amino-5 alpha-cholestane 10 showed the highest potency in these series toward the Gram-positive bacteria, Staphylococcus epidermidis 887E, with the lowest MIC value of 1 mu g/mL. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：4315 / 4318

页数：4

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