Tracking and fixed ranking of leukocyte telomere length across the adult life course

被引：180

作者：

Benetos, Athanase ^{[1
,2
]}

Kark, Jeremy D. ^{[3
]}

Susser, Ezra ^{[4
,5
]}

Kimura, Masayuki ^{[6
]}

Sinnreich, Ronit ^{[3
]}

Chen, Wei ^{[7
]}

Steenstrup, Troels ^{[8
,9
,10
]}

Christensen, Kaare ^{[8
,9
,10
]}

Herbig, Utz ^{[11
]}

Hjelmborg, Jacob von Bornemann ^{[8
,9
,10
]}

Srinivasan, Sathanur R. ^{[7
]}

Berenson, Gerald S. ^{[7
]}

Labat, Carlos ^{[1
,2
]}

Aviv, Abraham ^{[4
,6
]}

机构：

[1] Nancy Univ Hosp, Geriatr Serv, F-54511 Nancy, France

[2] Univ Lorraine, INSERM, U1116, Fac Med, F-54500 Nancy, France

[3] Hebrew Univ Jerusalem, Hadassah Sch Publ Hlth & Community Med, Jerusalem, Israel

[4] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10032 USA

[5] New York State Psychiat Inst & Hosp, New York, NY 10032 USA

[6] Univ Med & Dent New Jersey, New Jersey Med Sch, Ctr Human Dev & Aging, Newark, NJ 07103 USA

[7] Tulane Univ, Ctr Cardiovasc Hlth, New Orleans, LA 70118 USA

[8] Univ Southern Denmark, Epidemiol Unit, Inst Publ Hlth, Danish Twin Registry, Odense, Denmark

[9] Univ Southern Denmark, Stat Unit, Inst Publ Hlth, Danish Twin Registry, Odense, Denmark

[10] Univ Southern Denmark, Danish Aging Res Ctr, Odense, Denmark

[11] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Microbiol & Mol Genet, Newark, NJ 07103 USA

来源：

AGING CELL | 2013年 / 12卷 / 04期

基金：

以色列科学基金会;

关键词：

human; leukocytes; longitudinal; Southern blots; telomeres; LONGITUDINAL FINDINGS; CIGARETTE-SMOKING; PHYSICAL-ACTIVITY; ASSOCIATION; HEART; TESTS; LIVER;

D O I：

10.1111/acel.12086

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Short leukocyte telomere length (LTL) is associated with atherosclerosis in adults and diminished survival in the elderly. LTL dynamics are defined by LTL at birth, which is highly variable, and its age-dependent attrition thereafter, which is rapid during the first 20years of life. We examined whether age-dependent LTL attrition during adulthood can substantially affect individuals' LTL ranking (e.g., longer or shorter LTL) in relation to their peers. We measured LTL in samples donated 12years apart on average by 1156 participants in four longitudinal studies. We observed correlations of 0.91-0.96 between baseline and follow-up LTLs. Ranking individuals by deciles revealed that 94.1% (95% confidence interval of 92.6-95.4%) showed no rank change or a 1 decile change over time. We conclude that in adults, LTL is virtually anchored to a given rank with the passage of time. Accordingly, the links of LTL with atherosclerosis and longevity appear to be established early in life. It is unlikely that lifestyle and its modification during adulthood exert a major impact on LTL ranking.

引用

页码：615 / 621

页数：7

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