Evaluation of a fast single-photon avalanche photodiode for measurement of early transmitted photons through diffusive media

被引:7
作者
Mu, Ying [1 ]
Valim, Niksa [1 ]
Niedre, Mark [1 ]
机构
[1] Northeastern Univ, Dept Elect & Comp Engn, Boston, MA 02115 USA
基金
美国国家卫生研究院;
关键词
FLUORESCENCE TOMOGRAPHY; OPTICAL TOMOGRAPHY; TIME;
D O I
10.1364/OL.38.002098
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
We tested the performance of a fast single-photon avalanche photodiode (SPAD) in measurement of early transmitted photons through diffusive media. In combination with a femtosecond titanium: sapphire laser, the overall instrument temporal response time was 59 ps. Using two experimental models, we showed that the SPAD allowed measurement of photon-density sensitivity functions that were approximately 65% narrower than the ungated continuous wave case at very early times. This exceeds the performance that we have previously achieved with photomultiplier-tube-based systems and approaches the theoretical maximum predicted by time-resolved Monte Carlo simulations. (c) 2013 Optical Society of America
引用
收藏
页码:2098 / 2100
页数:3
相关论文
共 9 条
[1]   TIME-RESOLVED TRANSILLUMINATION FOR MEDICAL DIAGNOSTICS [J].
ANDERSSONENGELS, S ;
BERG, R ;
SVANBERG, S ;
JARLMAN, O .
OPTICS LETTERS, 1990, 15 (21) :1179-1181
[2]   Optical tomography in medical imaging [J].
Arridge, SR .
INVERSE PROBLEMS, 1999, 15 (02) :R41-R93
[3]   Hybrid use of early and quasi-continuous wave photons in time-domain tomographic imaging for improved resolution and quantitative accuracy [J].
Li, Zhi ;
Niedre, Mark .
BIOMEDICAL OPTICS EXPRESS, 2011, 2 (03) :665-679
[4]   Time-resolved imaging of optical coefficients through murine chest cavities [J].
Niedre, Mark J. ;
Turner, Gordon M. ;
Ntziachristos, Vasilis .
JOURNAL OF BIOMEDICAL OPTICS, 2006, 11 (06)
[5]   Hybrid Small Animal Imaging System Combining Magnetic Resonance Imaging With Fluorescence Tomography Using Single Photon Avalanche Diode Detectors [J].
Stuker, Florian ;
Baltes, Christof ;
Dikaiou, Katerina ;
Vats, Divya ;
Carrara, Lucio ;
Charbon, Edoardo ;
Ripoll, Jorge ;
Rudin, Markus .
IEEE TRANSACTIONS ON MEDICAL IMAGING, 2011, 30 (06) :1265-1273
[6]   Fast-gated single-photon counting technique widens dynamic range and speeds up acquisition time in time-resolved measurements [J].
Tosi, Alberto ;
Dalla Mora, Alberto ;
Zappa, Franco ;
Gulinatti, Angelo ;
Contini, Davide ;
Pifferi, Antonio ;
Spinelli, Lorenzo ;
Torricelli, Alessandro ;
Cubeddu, Rinaldo .
OPTICS EXPRESS, 2011, 19 (11) :10735-10746
[7]   The effect of temporal impulse response on experimental reduction of photon scatter in time-resolved diffuse optical tomography [J].
Valim, Niksa ;
Brock, James ;
Leeser, Miriam ;
Niedre, Mark .
PHYSICS IN MEDICINE AND BIOLOGY, 2013, 58 (02) :335-349
[8]   Full-field time-resolved fluorescence tomography of small animals [J].
Venugopal, Vivek ;
Chen, Jin ;
Lesage, Frederic ;
Intes, Xavier .
OPTICS LETTERS, 2010, 35 (19) :3189-3191
[9]   Fluorescence tomographic imaging in turbid media using early-arriving photons and Laplace transforms [J].
Wu, J ;
Perelman, L ;
Dasari, RR ;
Feld, MS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (16) :8783-8788