The Possible Future Roles for iPSC-Derived Therapy for Autoimmune Diseases

被引：14

作者：

Hew, Meilyn ^{[1
]}

O'Connor, Kevin ^{[2
]}

Edel, Michael J. ^{[3
,4
,5
]}

Lucas, Michaela ^{[1
,6
,7
,8
]}

机构：

[1] Queen Elizabeth II Med Ctr, Dept Clin Immunol, Pathwest Lab Med, Perth, WA 6009, Australia

[2] Royal Perth Hosp, Dept Clin Immunol, Perth, WA 6000, Australia

[3] Univ Barcelona, Hosp Clin, Dept Physiol Sci 1, Control Pluripotency Lab,Fac Med, E-08036 Barcelona, Spain

[4] Victor Chang Cardiac Res Inst, Sydney, NSW 2010, Australia

[5] Univ Western Australia, CCTRM, Sch Med & Pharmacol Anat Physiol & Human Biol, Perth, WA 6009, Australia

[6] Univ Western Australia, Harry Perkins Inst Med Res, Sch Med & Pharmacol, Perth, WA 6009, Australia

[7] Univ Western Australia, Harry Perkins Inst Med Res, Sch Pathol & Lab Med, Perth, WA 6009, Australia

[8] Murdoch Univ, Inst Immunol & Infect Dis, Perth, WA 6150, Australia

来源：

JOURNAL OF CLINICAL MEDICINE | 2015年 / 4卷 / 06期

关键词：

inducible; pluripotent; stem cells; autoimmunity; therapy; lupus; diabetes; multiple sclerosis; PLURIPOTENT STEM-CELLS; REGULATORY T-CELLS; ANTIGEN-SPECIFIC SUPPRESSION; MULTIPLE-SCLEROSIS; DENDRITIC CELLS; RHEUMATOID-ARTHRITIS; RISK-FACTORS; IN-VIVO; GENERATION; DIFFERENTIATION;

D O I：

10.3390/jcm4061193

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The ability to generate inducible pluripotent stem cells (iPSCs) and the potential for their use in treatment of human disease is of immense interest. Autoimmune diseases, with their limited treatment choices are a potential target for the clinical application of stem cell and iPSC technology. IPSCs provide three potential ways of treating autoimmune disease; (i) providing pure replacement of lost cells (immuno-reconstitution); (ii) through immune-modulation of the disease process in vivo; and (iii) for the purposes of disease modeling in vitro. In this review, we will use examples of systemic, system-specific and organ-specific autoimmunity to explore the potential applications of iPSCs for treatment of autoimmune diseases and review the evidence of iPSC technology in auto-immunity to date.

引用

页码：1193 / 1206

页数：14

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