The genus Rosa and arthritis: Overview on pharmacological perspectives

被引：41
作者：
Cheng, Brian Chi Yan [1 ]
Fu, Xiu-Qiong [1 ]
Guo, Hui [1 ]
Li, Ting [1 ]
Wu, Zheng-Zhi [2 ]
Chan, Kelvin [3 ,4 ]
Yu, Zhi-Ling [1 ]
机构：
[1] Hong Kong Baptist Univ, Sch Chinese Med, Ctr Canc & Inflammat Res, Hong Kong, Hong Kong, Peoples R China
[2] Shenzhen Inst Geriatr, Shenzhen, Peoples R China
[3] Liverpool John Moores Univ, Sch Pharm & Biomol Sci, Liverpool L3 3AF, Merseyside, England
[4] Univ Technol Sydney, Fac Sci, Sydney, NSW 2007, Australia
来源：
PHARMACOLOGICAL RESEARCH | 2016年 / 114卷
基金：
中国国家自然科学基金;
关键词：
Rose hips; Rosa canina; Rosa multiflora; Ursolic acid; 13-sitosterol; Rheumatoid arthritis; NF-KAPPA-B; LAEVIGATA MICHX FRUIT; RHEUMATOID-ARTHRITIS; DOUBLE-BLIND; HIP POWDER; ANTIINFLAMMATORY ACTIVITIES; INFLAMMATORY RESPONSES; ANTIOXIDATIVE ACTIVITY; CHEMICAL-CONSTITUENTS; CONDENSED TANNINS;
D O I：
10.1016/j.phrs.2016.10.029
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The genus Rosa (roses) has long been used in traditional or folk medicine worldwide for the treatment of various types of arthritis including rheumatoid arthritis and osteoarthritis. The active constituents of Rosa spp., such as flavonoids, triterpenoids, and phytosterols, could act on different targets in the NF-kappa B signalling pathway, inhibit pro-inflammatory enzymes (e.g. MMPs and COX-2), lower the production of inflammatory cytokines and chemokines (e.g. TNF-alpha, IL-1 beta, IL-6, CCL5), and reduce oxidative stress, which in turn suppress inflammatory processes. Preclinical and clinical studies have demonstrated that these species possess analgesic, anti-arthritic, anti-inflammatory, anti-oxidative and bone-preserving activities. This review presents comprehensive overview of the mode and mechanism of action of various extracts, preparations, and active constituents from this genus. The dynamic beneficial effects of the products prepared from this genus in arthritis management are summarized. The Rosa genus is a treasure waiting for further exploration by researchers interested in the development of safe and effective anti arthritic agents. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：219 / 234
页数：16
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