Reversible RNA modifications in meiosis and pluripotency

被引：28

作者：

Klungland, Arne ^{[1
,2
,3
]}

Dahl, John Arne ^{[1
]}

Greggains, Gareth ^{[4
]}

Fedorcsak, Peter ^{[4
]}

Filipczyk, Adam ^{[1
,3
]}

机构：

[1] Natl Hosp Norway, Oslo Univ Hosp, Dept Microbiol, Oslo, Norway

[2] Univ Oslo, Inst Basic Med Sci, Dept Mol Med, Oslo, Norway

[3] Natl Hosp Norway, Oslo Univ Hosp, Norwegian Ctr Stem Cell Res, Oslo, Norway

[4] Natl Hosp Norway, Oslo Univ Hosp, Sect Reprod Med, Dept Gynecol, Oslo, Norway

来源：

NATURE METHODS | 2017年 / 14卷 / 01期

关键词：

CONTROLS CELL FATE; MESSENGER-RNA; GENE-EXPRESSION; MAPPING REVEALS; WOBBLE POSITION; NUCLEAR-RNA; METHYLATION; N-6-METHYLADENOSINE; TRANSCRIPTION; TRANSLATION;

D O I：

10.1038/nmeth.4111

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Post-transcriptional RNA modifications were discovered several decades ago, but the reversible nature of RNA modifications has only recently been discovered. Owing to technological advances, knowledge of epitranscriptomic marks and their writers, readers and erasers has recently advanced tremendously. Here we focus on the roles of the dynamic methylation and demethylation of internal adenosines in mRNA in germ cells and pluripotent stem cells. © 2017 Nature America, Inc., part of Springer Nature. All rights reserved.

引用

页码：18 / 22

页数：5

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