Defective antigen-induced lymphocyte proliferation in the X-linked hyper-IgM syndrome

被引：52

作者：

Ameratunga, R

Lederman, HM

Sullivan, KE

Ochs, HD

Seyama, K

French, JK

Prestidge, R

Marbrook, J

Fanslow, WC

Winkelstein, JA

机构：

[1] UNIV AUCKLAND, DEPT MOL MED, AUCKLAND 1, NEW ZEALAND

[2] JOHNS HOPKINS UNIV, DEPT PEDIAT, DIV IMMUNOL, BALTIMORE, MD 21218 USA

来源：

JOURNAL OF PEDIATRICS | 1997年 / 131卷 / 01期

关键词：

D O I：

10.1016/S0022-3476(97)70139-2

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We examined T-cell proliferation in five patients with X-linked hyper-IgM syndrome (XHIM), using a panel of antigens and lectins. ALL patients had Impaired antigen-induced proliferation, whereas their lectin responses were normal. Thus, in addition to severely depressed antibody responses, patients with XHIM have a defect in antigen-specific T-cell proliferation, which may explain their susceptibility to pathogens such as Pneumocystis carinii.

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收藏

页码：147 / 150

页数：4

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