Copper-Catalyzed Regioselective Hydroalkylation of 1,3-Dienes with Alkyl Fluorides and Grignard Reagents

被引：39

作者：

Iwasaki, Takanori ^{[1
]}

Shimizu, Ryohei ^{[1
]}

Imanishi, Reiko ^{[1
]}

Kuniyasu, Hitoshi ^{[1
]}

Kambe, Nobuaki ^{[1
]}

机构：

[1] Osaka Univ, Dept Appl Chem, Grad Sch Engn, Suita, Osaka 5650871, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2015年 / 54卷 / 32期

关键词：

alkylation; chemoselectivity; copper; magnesium; synthetic methods; CROSS-COUPLING REACTION; F BOND ACTIVATION; CARBONYL-COMPOUNDS; 1,4-ARYLATION ALKYLATION; TRANSFER HYDROGENATION; METAL-COMPLEXES; HALIDES; NICKEL; DIENES; ALCOHOL;

D O I：

10.1002/anie.201503288

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Copper complexes generated insitu from CuCl2, alkyl Grignard reagents, and 1,3-dienes play important roles as catalytic active species for the 1,2-hydroalkylation of 1,3-dienes by alkyl fluorides through CF bond cleavage. The alkyl group is introduced to an internal carbon atom of the 1,3-diene regioselectively, thus giving rise to the branched terminal alkene product.

引用

页码：9347 / 9350

页数：4

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