Novel Indole Alkaloids from Nauclea latifolia and Their Renin-Inhibitory Activities

被引：24

作者：

Agomuoh, Anthony A. ^{[1
,2
]}

Ata, Athar ^{[2
]}

Udenigwe, Chibuike C. ^{[3
]}

Aluko, Rotimi E. ^{[3
]}

Irenus, Iwu ^{[4
]}

机构：

[1] Univ Winnipeg, Dept Biol, Richardson Coll Environm & Sci Complex, Winnipeg, MB R3B 2G3, Canada

[2] Univ Winnipeg, Dept Chem, Richardson Coll Environm & Sci Complex, Winnipeg, MB R3B 2G3, Canada

[3] Univ Manitoba, Dept Human Nutr Sci, Winnipeg, MB R3T 2N2, Canada

[4] Fed Univ Technol, Dept Ind Chem, Owerri, Niger

来源：

CHEMISTRY & BIODIVERSITY | 2013年 / 10卷 / 03期

关键词：

Nauclea latifolia; Renin-inhibitory activity; Indole alkaloids; Alkaloids; Latifoliamides AE; Angustoline; Inhibitors; Antihypertensive activity; CHEMICAL-CONSTITUENTS;

D O I：

10.1002/cbdv.201200023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chemical studies on the crude MeOH extract of stems and barks of Nauclea latifolia resulted in the isolation of five new indole alkaloids, latifoliamides AE (15, resp.), along with one known alkaloid, angustoline (6). The structures of these compounds were elucidated by means of extensive NMR spectral studies. Compound 1 has a 20-ethylidenetetrahydrofuran ring incorporated in its structure and represents the first example of this class of indole alkaloids. All of the isolates exhibited moderate in vitro renin inhibitory activities.

引用

页码：401 / 410

页数：10

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