Complete Epstein-Barr virus seropositivity in a large cohort of patients with early multiple sclerosis

被引：74

作者：

Abrahamyan, Sargis ^{[1
,2
]}

Eberspaecher, Bettina ^{[3
]}

Hoshi, Muna-Miriam ^{[4
]}

Aly, Lilian ^{[4
]}

Luessi, Felix ^{[5
]}

Groppa, Sergiu ^{[5
]}

Klotz, Luisa ^{[6
]}

Meuth, Sven G. ^{[6
]}

Schroeder, Christoph ^{[7
]}

Grueter, Thomas ^{[7
]}

Tackenberg, Bjoern ^{[8
]}

Paul, Friedemann ^{[1
,9
]}

Then-Bergh, Florian ^{[10
]}

Kuempfel, Tania ^{[11
]}

Weber, Frank ^{[12
]}

Stangel, Martin ^{[13
]}

Bayas, Antonios ^{[14
]}

Wildemann, Brigitte ^{[15
]}

Heesen, Christoph ^{[16
]}

Zettl, Uwe ^{[17
]}

Warnke, Clemens ^{[18
,19
,20
]}

Antony, Gisela ^{[21
]}

Hessler, Nicole ^{[22
]}

Wiendl, Heinz ^{[6
]}

Bittner, Stefan ^{[5
]}

Hemmer, Bernhard ^{[4
]}

Gold, Ralf ^{[7
]}

Salmen, Anke ^{[23
]}

Ruprecht, Klemens ^{[1
]}

机构：

[1] Charite Univ Med Berlin, Dept Neurol, Charitepl 1, D-10117 Berlin, Germany

[2] Yerevan State Univ, Yerevan, Armenia

[3] Lab Berlin Charite Vivantes GmbH, Berlin, Germany

[4] Tech Univ Munich, Dept Neurol, Klinikum Rechts Isar, Munich, Germany

[5] Johannes Gutenberg Univ Mainz, Univ Med Mainz, Dept Neurol, Mainz, Germany

[6] Univ Munster, Dept Neurol, Inst Translat Neurol, Munster, Germany

[7] Ruhr Univ Bochum, Dept Neurol, St Josef Hosp, Bochum, Germany

[8] Philipps Univ Marburg, Dept Neurol, Marburg, Germany

[9] Charite Univ Med Berlin, NeuroCure Clin Res Ctr, Berlin, Germany

[10] Univ Leipzig, Dept Neurol, Leipzig, Germany

[11] Ludwig Maximilians Univ Munchen, Inst Clin Neuroimmunol, Munich, Germany

[12] Sana Kliniken Landkreises Cham, Neurol Clin, Cham, Germany

[13] Hannover Med Sch, Dept Neurol, Clin Neuroimmunol & Neurochem, Hannover, Germany

[14] Univ Klinikum Augsburg, Dept Neurol, Augsburg, Germany

[15] Heidelberg Univ, Dept Neurol, Heidelberg, Germany

[16] Univ Hosp Hamburg Eppendorf, Dept Neurol, Hamburg, Germany

[17] Univ Rostock, Dept Neurol, Rostock, Germany

[18] Univ Cologne, Fac Med, Dept Neurol, Cologne, Germany

[19] Univ Hosp Cologne, Cologne, Germany

[20] Univ Dusseldorf, Dept Neurol, Dusseldorf, Germany

[21] Philipps Univ Marburg, Cent Informat Off CIO, Marburg, Germany

[22] Univ Hosp Schleswig Holstein, Inst Med Biometry & Stat, Campus Lubeck, Lubeck, Germany

[23] Univ Bern, Univ Hosp Bern, Dept Neurol, Inselspital, Bern, Switzerland

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 2020年 / 91卷 / 07期

关键词：

ENVIRONMENTAL RISK-FACTORS; INFECTION; PREVENTION; EBV;

D O I：

10.1136/jnnp-2020-322941

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective To determine the prevalence of antibodies to Epstein-Barr virus (EBV) in a large cohort of patients with early multiple sclerosis (MS). Methods Serum samples were collected from 901 patients with a clinically isolated syndrome (CIS) or early relapsing-remitting multiple sclerosis (RRMS) participating in the German National MS cohort, a prospective cohort of patients with early MS with stringent inclusion criteria. Epstein-Barr nuclear antigen (EBNA)-1 and viral capsid antigen (VCA) antibodies were measured in diluted sera by chemiluminescence immunoassays (CLIAs). Sera of EBNA-1 and VCA antibody-negative patients were retested undiluted by an EBV IgG immunoblot. For comparison, we retrospectively analysed the EBV seroprevalence across different age cohorts, ranging from 0 to >80 years, in a large hospital population (N=16 163) from Berlin/Northern Germany. Results EBNA-1 antibodies were detected by CLIA in 839 of 901 patients with CIS/RRMS. Of the 62 patients without EBNA-1 antibodies, 45 had antibodies to VCA as detected by CLIA. In all of the remaining 17 patients, antibodies to EBV were detected by immunoblot. Altogether, 901 of 901 (100%) patients with CIS/RRMS were EBV-seropositive. EBV seropositivity increased with age in the hospital population but did not reach 100% in any of the investigated age cohorts. Conclusion The complete EBV seropositivity in this large cohort of patients with early MS strengthens the evidence for a role of EBV in MS. It also suggests that a negative EBV serology in patients with suspected inflammatory central nervous system disease should alert clinicians to consider diagnoses other than MS.

引用

页码：681 / 686

页数：6

共 26 条

[1] Systematic Review and Meta-Analysis of the Sero-Epidemiological Association between Epstein Barr Virus and Multiple Sclerosis [J].

Almohmeed, Yahya H. ;

Avenell, Alison ;

Aucott, Lorna ;

Vickers, Mark A. .

PLOS ONE, 2013, 8 (04)

[2] Environmental risk factors for multiple sclerosis. Part I: The role of infection [J].

Ascherio, Alberto ;

Munger, Kassandra L. .

ANNALS OF NEUROLOGY, 2007, 61 (04) :288-299

[3] Epidemiology of Multiple Sclerosis: From Risk Factors to Prevention-An Update [J].

Ascherio, Alberto ;

Munger, Kassandra L. .

SEMINARS IN NEUROLOGY, 2016, 36 (02) :103-114

[4] The initiation and prevention of multiple sclerosis [J].

Ascherio, Alberto ;

Munger, Kassandra L. ;

Luenemann, Jan D. .

NATURE REVIEWS NEUROLOGY, 2012, 8 (11) :602-612

[5] Age-Specific Prevalence of Epstein-Barr Virus Infection Among Individuals Aged 6-19 Years in the United States and Factors Affecting Its Acquisition [J].

Balfour, Henry H., Jr. ;

Sifakis, Frangiscos ;

Sliman, Joseph A. ;

Knight, Jennifer A. ;

Schmeling, David O. ;

Thomas, William .

JOURNAL OF INFECTIOUS DISEASES, 2013, 208 (08) :1286-1293

[6] Behavioral, Virologic, and Immunologic Factors Associated With Acquisition and Severity of Primary Epstein-Barr Virus Infection in University Students [J].

Balfour, Henry H., Jr. ;

Odumade, Oludare A. ;

Schmeling, David O. ;

Mullan, Beth D. ;

Ed, Julie A. ;

Knight, Jennifer A. ;

Vezina, Heather E. ;

Thomas, William ;

Hogquist, Kristin A. .

JOURNAL OF INFECTIOUS DISEASES, 2013, 207 (01) :80-88

[7] Environmental risk factors and multiple sclerosis: an umbrella review of systematic reviews and meta-analyses [J].

Belbasis, Lazaros ;

Bellou, Vanesa ;

Evangelou, Evangelos ;

Ioannidis, John P. A. ;

Tzoulaki, Ioanna .

LANCET NEUROLOGY, 2015, 14 (03) :263-273

[8] Multiple sclerosis [J].

Compston, Alastair ;

Coles, Alasdair .

LANCET, 2008, 372 (9648) :1502-1517

[9] Seroepidemiology of EBV and Interpretation of the "Isolated VCA IgG" Pattern [J].

De Paschale, Massimo ;

Agrappi, Carlo ;

Manco, Maria Teresa ;

Mirri, Paola ;

Vigano, Egidio Franco ;

Clerici, Pierangelo .

JOURNAL OF MEDICAL VIROLOGY, 2009, 81 (02) :325-331

[10] Are there Epstein-Barr virus seronegative patients with multiple sclerosis? [J].

Deuschle, Katrin ;

Hofmann, Joerg ;

Otto, Carolin ;

Bellmann-Strobl, Judith ;

Scherner, Oskar ;

Klumbies, Katharina ;

Schneider, Elisa ;

Broddack, Julian ;

Paul, Friedemann ;

Ruprecht, Klemens .

MULTIPLE SCLEROSIS JOURNAL, 2013, 19 (09) :1242-1243

← 1 2 3 →