Decoy activity through microRNAs: the therapeutic implications

被引：27

作者：

Almeida, Maria Ines ^{[1
,2
]}

Reis, Rui Manuel ^{[2
,3
]}

Calin, George Adrian ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA

[2] Univ Minho, Life & Hlth Sci Res Inst ICVS, Sch Hlth Sci, P-4710057 Braga, Portugal

[3] Barretos Canc Hosp, Mol Oncol Res Ctr, Barretos, S Paulo, Brazil

来源：

EXPERT OPINION ON BIOLOGICAL THERAPY | 2012年 / 12卷 / 09期

关键词：

mimic; regulation; sponge; therapeutic potential; REGULATORY RNA; MESSENGER-RNAS; C-ELEGANS; HNRNP E2; GENE; TRANSCRIPTOME; EXPRESSION; BIOLOGY; LIN-14; PTEN;

D O I：

10.1517/14712598.2012.693470

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Introduction: microRNAs (miRNAs), small noncoding RNAs, are deregulated in several diseases including cancer. miRNAs regulate gene expression at a post-transcriptional level by binding to 5'UTR, coding regions or 3'UTR of messenger RNAs (mRNA), inhibiting mRNA translation or causing mRNA degradation. The same miRNA can have multiple mRNA targets, and the same mRNA can be regulated by various miRNAs. Areas covered: Recently, seminal contributions by several groups have implicated miRNAs as components of an RNA-RNA language that involves crosstalk between competing endogenous RNAs through a decoy mechanism. We review the studies that described miRNAs as players in a biological decoy activity. miRNAs can either be trapped by competing endogenous RNAs or interact with proteins that have binding sites for mRNAs. Expert opinion: The miRNA decoy functions have implications for the design of therapeutic approaches in human diseases, including specific ways to overcome resistance to drug therapy and future miRNA-based clinical trials design.

引用

页码：1153 / 1159

页数：7