Predictors and outcomes of linezolid-resistant vancomycin-resistant Enterococcus: A case-case-control study

被引：14

作者：

Hayakawa, Kayoko ^{[1
]}

Marchaim, Dror ^{[1
]}

Pogue, Jason M. ^{[2
]}

Ho, Kevin ^{[1
]}

Parveen, Shakila ^{[1
]}

Nanjireddy, Priyanka ^{[1
]}

Sunkara, Bharath ^{[1
]}

Singla, Manit ^{[1
]}

Jagadeesh, Kavyashri Kodlipet ^{[1
]}

Moshos, Judy A. ^{[1
]}

Bommarito, Sarah ^{[1
]}

Mroue, Rida ^{[1
]}

Farhat, Mohamad ^{[1
]}

Obeid, Tarek ^{[1
]}

Chaudhry, Aaisha ^{[1
]}

Vadlamudi, Gayathri ^{[1
]}

Lephart, Paul R. ^{[3
]}

Martin, Emily T. ^{[4
]}

Rybak, Michael J. ^{[1
,2
,4
,5
]}

Kaye, Keith S. ^{[1
]}

机构：

[1] Wayne State Univ, Detroit Med Ctr, Div Infect Dis, Detroit, MI 48201 USA

[2] Detroit Med Ctr, Dept Pharm Serv, Detroit, MI USA

[3] Detroit Med Ctr Univ Labs, Detroit, MI USA

[4] Wayne State Univ, Dept Pharm Practice, Eugene Applebaum Coll Pharm & Hlth Sci, Detroit, MI 48201 USA

[5] Wayne State Univ, Antiinfect Res Lab, Eugene Applebaum Coll Pharm & Hlth Sci, Detroit, MI 48201 USA

来源：

AMERICAN JOURNAL OF INFECTION CONTROL | 2012年 / 40卷 / 10期

关键词：

VRE; Enterococci; Multidrug resistant; Antimicrobial resistance; Gram positive; Hospital-acquired infections;

D O I：

10.1016/j.ajic.2012.06.009

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Linezolid is an important agent for the treatment of infections because of vancomycin-resistant Enterococcus (VRE). This study identified independent predictors for isolation of linezolid-resistant VRE (LZD-R-VRE) and analyzed outcomes associated with linezolid resistance. Immunosuppression, prior surgery, and previous exposure to beta-lactam antibiotics were independent predictors for isolation of LZD-R-VRE but not for LZD-susceptible-VRE. Prior exposure to linezolid was not a predictor for isolation of LZD-R-VRE. Copyright (C) 2012 by the Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

引用

页码：E261 / E263

页数：3

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