Eight new cytotoxic annonaceous acetogenins from the seeds of Annona squamosa

被引：0

作者：

Ma Cheng-Yao ^{[1
]}

Lu Jia-Hui ^{[1
]}

Li Xiang ^{[1
]}

Liu Xiao ^{[2
]}

Chen Jian-Wei ^{[1
]}

机构：

[1] Nanjing Univ Chinese Med, Pharmaceut Inst, Nanjing 210023, Jiangsu, Peoples R China

[2] State Minist Educ Standardizat Chinese Med Proc, Engn Ctr, Nanjing 210023, Jiangsu, Peoples R China

来源：

CHINESE JOURNAL OF NATURAL MEDICINES | 2019年 / 17卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Annona squamosa; Annonaceous acetogenins; Cytotoxicity; Multidrug resistance;

D O I：

暂无

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Eight new annonaceous acetogenins, squamotin A-D (1-4), annosquatin IV-V (5 and 6), muricin O (7) and squamosten B (8), together with four known ones (9-12) were isolated from the seeds of Annona squamosa. Their structures were elucidated by chemical methods and spectral data. The inhibitory activities of compound 1-9 against three multidrug resistance cell lines were evaluated. All tested compounds showed strong cytotoxicity.

引用

页码：291 / 297

页数：7

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