Eight new cytotoxic annonaceous acetogenins from the seeds of Annona squamosa

被引：0
|
作者：
Ma Cheng-Yao [1 ]
Lu Jia-Hui [1 ]
Li Xiang [1 ]
Liu Xiao [2 ]
Chen Jian-Wei [1 ]
机构：
[1] Nanjing Univ Chinese Med, Pharmaceut Inst, Nanjing 210023, Jiangsu, Peoples R China
[2] State Minist Educ Standardizat Chinese Med Proc, Engn Ctr, Nanjing 210023, Jiangsu, Peoples R China
来源：
CHINESE JOURNAL OF NATURAL MEDICINES | 2019年 / 17卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Annona squamosa; Annonaceous acetogenins; Cytotoxicity; Multidrug resistance;
D O I：
暂无
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
Eight new annonaceous acetogenins, squamotin A-D (1-4), annosquatin IV-V (5 and 6), muricin O (7) and squamosten B (8), together with four known ones (9-12) were isolated from the seeds of Annona squamosa. Their structures were elucidated by chemical methods and spectral data. The inhibitory activities of compound 1-9 against three multidrug resistance cell lines were evaluated. All tested compounds showed strong cytotoxicity.
引用
收藏
页码：291 / 297
页数：7
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