Application of fMRI to Obesity Research: Differences in Reward Pathway Activation measured with fMRI BOLD during Visual Presentation of High and Low Calorie Foods

被引:1
作者
Tsao, Sinchai [1 ]
Adam, Tanja C.
Goran, Michael I.
Singh, Manbir [1 ]
机构
[1] Univ So Calif, Dept Biomed Engn, Viterbi Sch Engn, Los Angeles, CA 90089 USA
来源
MEDICAL IMAGING 2012: BIOMEDICAL APPLICATIONS IN MOLECULAR, STRUCTURAL, AND FUNCTIONAL IMAGING | 2012年 / 8317卷
关键词
fMRI; MRI; Obesity; Reward Pathway; Food; Dopamine; INSULIN SENSITIVITY; IMAGES; BRAIN;
D O I
10.1117/12.911854
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
The factors behind the neural mechanisms that motivate food choice and obesity are not well known. 1, 2 Furthermore, it is not known when these neural mechanisms develop and how they are influenced by both genetic and environmental factors. This study uses fMRI together with clinical data to shed light on the aforementioned questions by investigating how appetite-related activation in the brain changes with low versus high caloric foods in pre-pubescent girls. Previous studies have shown that obese adults have less striatal D2 receptors and thus reduced Dopamine (DA) signaling leading to the reward-deficit theory of obesity. 3, 4 However, overeating in itself reduces D2 receptor density, D2 sensitivity and thus reward sensitivity. The results of this study will show how early these neural mechanisms develop and what effect the drastic endocrinological changes during puberty has on these mechanisms. Our preliminary results showed increased activations in the Putamen, Insula, Thalamus and Hippocampus when looking at activations where High Calorie > Low Calorie. When comparing High Calorie > Control and Low Calorie > Control, the High > Control test showed increased significant activation in the frontal lobe. The Low > Control also yielded significant activation in the Left and Right Fusiform Gyrus, which did not appear in the High > Control test. These results indicate that the reward pathway activations previously shown in post-puberty and adults are present in pre-pubescent teens. These results may suggest that some of the preferential neural mechanisms of reward are already present pre-puberty.
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页数:6
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