The synthesis of 4-benzylamino-6-methyl-1H-pyrrolo[3,2-c]pyridine and 4-benzylamino-6-methyl-1H-pyrrolo[2,3-b]pyridine

被引：13
作者：
Meade, EA
Beauchamp, LM
机构：
[1] Division of Organic Chemistry, Glaxo Wellcome Co., Research Triangle Park
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 1996年 / 33卷 / 02期
关键词：
D O I：
10.1002/jhet.5570330215
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
4-Benzylamino-6-methyl-1H-pyrrolo[3,2-c](2) and 4-benzylamino-6-methyl-1H-pyrrolo[2,3-b]pyridine (3) were synthesized as deaza analogues of the anxiolytic agent 4-benzylamino-2-methyl-7H-pyrrolo[2,3-d]pyrimidine (1). The 1-deaza analogue (2) was prepared via a multi-step procedure from a pyrrole precursor, 1-benzyl-2-formylpyrrole (4) while the 3-deaza analogue 3 was synthesized from a pyridine precursor, 2-amino-3,6-dimethylpyridine (12).
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页码：303 / 308
页数：6
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