A FIRST-IN-HUMAN TRIAL OF AN INTEGRIN BETA-6 TARGETED ANTIBODY-DRUG CONJUGATE (ADC), SGNB6A, IN PATIENTS WITH ADVANCED SOLID TUMORS: INTERIM RESULTS OF A PHASE 1 STUDY (SGNB6A-001)

被引：1

作者：

Hollebecque, Antoine ^{[1
]}

Lopez, Juanita ^{[2
]}

Piha-Paul, Sarina ^{[3
]}

Dowlati, Afshin ^{[4
]}

Patnaik, Amita ^{[5
]}

Galvao, Vladimir ^{[6
]}

Buckorny, Bruno ^{[7
]}

Sehgal, Kartik ^{[8
]}

Kingsley, Edwin ^{[9
]}

Sanborn, Rachel ^{[10
]}

Peters, Solange ^{[11
]}

Sun, Yan ^{[12
]}

Patilea-Vrana, Gabriela ^{[12
]}

Nazarenko, Natalya ^{[12
]}

Calvo, Emiliano ^{[13
]}

机构：

[1] Inst Gustave Roussy, Villejuif, France

[2] Royal Marsden Hosp Surrey, London, England

[3] Univ Texas Houston, Houston, TX USA

[4] Case Western Reserve Univ, Cleveland, OH USA

[5] START San Antonio, San Antonio, TX USA

[6] Vall dHebron Inst Oncol, Barcelona, Spain

[7] Beth Israel Deaconess Med Ctr, Boston, MA USA

[8] Dana Farber Canc Inst, Boston, MA USA

[9] Comprehens Canc Ctr Nevada, Las Vegas, NV USA

[10] Earle A Chiles Res Inst, Portland, OR USA

[11] CHU Vaudois, Lausanne, Switzerland

[12] Seagen Inc, Bothell, WA USA

[13] START Madrid CIOCC, Madrid, Spain

来源：

JOURNAL FOR IMMUNOTHERAPY OF CANCER | 2022年 / 10卷

关键词：

D O I：

10.1136/jitc-2022-SITC2022.0731

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

731

引用

页码：A763 / A763

页数：1

共 50 条

[1] SGN-B6A, an integrin beta-6 (ITGB6)-targeted antibody-drug conjugate (ADC), in patients with advanced solid tumors: Updated results from a phase 1 study (SGNB6A-001) [J].

Hollebecque, Antoine ;

Lopez, Juanita Suzanne ;

Piha-Paul, Sarina A. ;

Dowlati, Afshin ;

Patnaik, Amita ;

Galvao, Vladimir ;

Bockorny, Bruno ;

Sehgal, Kartik ;

Kingsley, Ed ;

Sanborn, Rachel E. ;

Perez, Cesar Augusto ;

Peters, Solange ;

Yan, Mingjin ;

Nazarenko, Natalya N. ;

Calvo, Emiliano .

JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)

[2] A phase 1 study of SGN-B6A, an antibody-drug conjugate targeting integrin beta-6, in patients with advanced solid tumors (SGNB6A-001, Trial in Progress). [J].

Patnaik, Amita ;

Calvo, Emiliano ;

Piha-Paul, Sarina Anne Anne ;

Hollebecque, Antoine ;

Galvao, Vladimir ;

Lopez, Juanita Suzanne ;

Braiteh, Fadi S. ;

Sanborn, Rachel E. ;

Zhou, Peigen ;

Nazarenko, Natalya N. ;

Dowlati, Afshin .

JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (15)

[3] A first-in-human trial of the integrin beta-6-targeted antibody-drug conjugate, SGN-B6A, in patients with advanced solid tumors [J].

Calvo, E. ;

Hollebecque, A. ;

Dowlati, A. ;

Piha-Paul, S. A. ;

Galvao, V. ;

Lopez, J. ;

Sehgal, K. ;

Bockorny, B. ;

Braiteh, F. ;

Peters, S. ;

Sanborn, R. E. ;

Zhou, P. ;

Nazarenko, N. ;

Patnaik, A. .

ANNALS OF ONCOLOGY, 2021, 32 :S613-S613

[4] Initial results of dose finding in a first-in-human phase 1 study of a novel Claudin 6 (CLDN6) targeted antibody drug conjugate (ADC) TORL-1-23 in patients with advanced solid tumors. [J].

Konecny, Gottfried E. ;

Hendrickson, Andrea Elisabeth Wahner ;

Winterhoff, Boris ;

Chander, Cinthiya ;

Bilic, Sanela ;

Davenport, Simon ;

Chung, Adrine ;

Miller, Lei-Lani ;

Press, Michael F. ;

Letrent, Stephen P. ;

Slamon, Dennis J. .

JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)

[5] A first-in-human (FIH) phase 1 study of SHR-A1921, a TROP-2 targeted antibody-drug conjugate (ADC), in patients with advanced solid tumors [J].

Wang, Jie ;

Wu, Lin ;

Song, Zhengbo ;

Li, Xingya ;

Liu, Caigang ;

Liu, Tianshu ;

Wu, Yiwen ;

Zhang, Ze ;

Wang, Shuni .

CANCER RESEARCH, 2023, 83 (08)

[6] First-in-human study of ABBV-706, a seizure-related homolog protein 6 (SEZ6)-targeting antibody-drug conjugate (ADC), in patients (pts) with advanced solid tumors. [J].

Chandana, Sreenivasa R. ;

Choudhury, Noura J. ;

Dowlati, Afshin ;

Chiang, Anne C. ;

Garmezy, Benjamin ;

Kim, Joo-Hang ;

Byers, Lauren Averett ;

Ahn, Myung-Ju ;

Kim, Tae Min ;

Kim, Young-Chul ;

Han, Ji-Youn ;

Bar, Jair ;

Zha, Jiuhong ;

Henner, William ;

Robinson, Randy ;

Kohlhapp, Fred ;

Hingorani, Pooja ;

Papadopoulos, Kyriakos P. .

JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)

[7] First-in-human phase I study of a novel claudin 6 (CLDN6) targeted antibody drug conjugate (ADC) TORL-1-23 [J].

Konecny, G. E. ;

Hendrickson, A. E. Wahner ;

Winterhoff, B. ;

Machado, A. ;

Chander, C. ;

Davenport, S. ;

Bilic, S. ;

Miller, L. L. ;

Chung, A. ;

Press, M. F. ;

Letrent, S. ;

Slamon, D. .

ANNALS OF ONCOLOGY, 2023, 34 :S517-S517

[8] FIRST-IN-HUMAN PHASE 1 STUDY OF TORL-1-23, A NOVEL CLAUDIN 6 (CLDN6) TARGETED ANTIBODY DRUG CONJUGATE (ADC) IN PATIENTS WITH OVARIAN CANCER [J].

Konecny, Gottfried ;

Hendrickson, Andrea Wahner ;

Winterhoff, Boris ;

Chander, Cinthiya ;

Bilic, Sanela ;

Davenport, Simon ;

Chung, Adrine ;

Miller, Lei-Lani ;

Press, Michael ;

Letrent, Stephen ;

Slamon, Dennis .

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2023, 33 (SUPPL_4) :A67-A67

[9] Preliminary results from a first-in-human trial of AMT-116, a topoisomerase I inhibitor containing antibody-drug conjugate (ADC), in patients with advanced solid tumors [J].

Coward, Jim ;

Kichenadasse, Ganessan ;

Park, John J. ;

Parakh, Sagun ;

Richardson, Gary Edward ;

Voskoboynik, Mark ;

Powderly, John D., II ;

Song, Zhengbo ;

Liu, Shutong ;

Huang, Yaling ;

Liu, Shu-Hui ;

Meng, Xun .

JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)

[10] Phase I, two-part, mutlicenter, first-in-human (FIH) study of TORL-1-23, a novel claudin 6 (CLDN6) targeting antibody drug conjugate (ADC) in patients with advanced solid tumors [J].

Konecny, Gottfried ;

Hendrickson, Andrea Wahner ;

Winterhoff, Boris ;

Kung, Adrine ;

Miller, Lei-Lani ;

Press, Michael ;

Qazi, Ibrahim ;

Scholler, Nathalie ;

Dokainish, Hatem ;

Letrent, Stephen ;

Slamon, Dennis .

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2024, 34 (SUPPL_3) :A56-A56

← 1 2 3 4 5 →