Concurrent pathology;
corticobasal degeneration;
multiple system atrophy;
Parkinsons disease;
progressive supra nuclear palsy;
synucleinopathy;
tauopathy;
D O I:
10.4103/0028-3886.91371
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
Corticobasal degeneration and Parkinson's disease are pathologically distinct disorders with unique histological and biochemical features of a tauopathy and alpha-synucleinopathy respectively. We report the first case of co-occurrence of these pathologies in the same patient. Convergence of such distinctly separate neuropathology in the same brain highlights the need for extensive brain banking and further research in supporting the hypothesis that tauopathies and alpha-synucleinopathies might share common pathogenic mechanisms.
机构:
All India Inst Med Sci, Dept Neurol, Rishikesh, Uttaranchal, IndiaAll India Inst Med Sci, Dept Neurol, Rishikesh, Uttaranchal, India
Jatale, Vinayak
Tiwari, Ashutosh
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机构:
All India Inst Med Sci, Dept Neurol, Rishikesh, Uttaranchal, IndiaAll India Inst Med Sci, Dept Neurol, Rishikesh, Uttaranchal, India
Tiwari, Ashutosh
Kumar, Mritunjai
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机构:
All India Inst Med Sci, Dept Neurol, Rishikesh, Uttaranchal, IndiaAll India Inst Med Sci, Dept Neurol, Rishikesh, Uttaranchal, India
Kumar, Mritunjai
Gupta, Ravi
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机构:
All India Inst Med Sci, Dept Psychiat, Rishikesh, Uttaranchal, India
All India Inst Med Sci, Div Sleep Med, Rishikesh, Uttaranchal, IndiaAll India Inst Med Sci, Dept Neurol, Rishikesh, Uttaranchal, India
Gupta, Ravi
Kumar, Niraj
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机构:
All India Inst Med Sci, Dept Neurol, Rishikesh, Uttaranchal, India
All India Inst Med Sci, Dept Neurol, Bibinagar, Telangana, India
All India Inst Med Sci, Dept Neurol, Bibinagar 508126, IndiaAll India Inst Med Sci, Dept Neurol, Rishikesh, Uttaranchal, India
机构:
Toronto Western Hosp, Morton & Gloria Shulman Movement Disorders Clin, Toronto, ON, Canada
Toronto Western Hosp, Edmond J Safra Program Parkinsons Dis, Toronto, ON, CanadaTech Univ Munich, Dept Neurol, Munich, Germany
机构:
Univ Sao Paulo, Hosp Clin, Fac Med, Dept Neurol, Sao Paulo, SP, BrazilUniv Sao Paulo, Hosp Clin, Fac Med, Dept Neurol, Sao Paulo, SP, Brazil
Parmera, Jacy Bezerra
Barbosa de Oliveira, Marcos Castello
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机构:
Univ Sao Paulo, Hosp Clin, Fac Med, Dept Neurol, Sao Paulo, SP, BrazilUniv Sao Paulo, Hosp Clin, Fac Med, Dept Neurol, Sao Paulo, SP, Brazil
Barbosa de Oliveira, Marcos Castello
Rodrigues, Roberta Diehl
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机构:
Univ Sao Paulo, Hosp Clin, Fac Med, Dept Neurol, Sao Paulo, SP, Brazil
Univ Sao Paulo, Dept Radiol, Fac Med, Lab Med Nucl LIM 44, Sao Paulo, SP, BrazilUniv Sao Paulo, Hosp Clin, Fac Med, Dept Neurol, Sao Paulo, SP, Brazil
Rodrigues, Roberta Diehl
Coutinho, Artur Martins
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机构:
Univ Sao Paulo, Hosp Clin, Fac Med, Ctr Med Nucl,Inst Radiol,Lab Med Nucl 43, Sao Paulo, SP, BrazilUniv Sao Paulo, Hosp Clin, Fac Med, Dept Neurol, Sao Paulo, SP, Brazil