Dual pathology of corticobasal degeneration and Parkinson's disease in a patient with clinical features of progressive supranuclear palsy

被引：4

作者：

Mooney, Tomin ^{[1
]}

Tampiyappa, Anthony ^{[2
]}

Robertson, Thomas ^{[3
]}

Grimley, Rohan ^{[2
]}

Burke, Chris ^{[3
]}

Ng, Kenneth ^{[2
]}

Patrikios, Peter ^{[1
]}

机构：

[1] Nambour Gen Hosp, Dept Neurol, Nambour, Qld 4560, Australia

[2] Nambour Gen Hosp, Dept Geriatr, Nambour, Qld 4560, Australia

[3] Royal Brisbane & Womens Hosp, Dept Anat Pathol, Brisbane, Qld, Australia

来源：

NEUROLOGY INDIA | 2011年 / 59卷 / 06期

关键词：

Concurrent pathology; corticobasal degeneration; multiple system atrophy; Parkinsons disease; progressive supra nuclear palsy; synucleinopathy; tauopathy;

D O I：

10.4103/0028-3886.91371

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Corticobasal degeneration and Parkinson's disease are pathologically distinct disorders with unique histological and biochemical features of a tauopathy and alpha-synucleinopathy respectively. We report the first case of co-occurrence of these pathologies in the same patient. Convergence of such distinctly separate neuropathology in the same brain highlights the need for extensive brain banking and further research in supporting the hypothesis that tauopathies and alpha-synucleinopathies might share common pathogenic mechanisms.

引用

页码：887 / 890

页数：4