Discrepancies between biomarkers of primary breast cancer and subsequent brain metastases: an international multicenter study

被引：27

作者：

Kaidar-Person, O. ^{[1
,2
,3
]}

Meattini, I. ^{[4
]}

Jain, P. ^{[5
]}

Bult, P. ^{[6
]}

Simone, N. ^{[7
]}

Kindts, I. ^{[8
,9
]}

Steffens, R. ^{[10
]}

Weltens, C. ^{[8
,9
]}

Navarria, P. ^{[11
]}

Belkacemi, Y. ^{[12
,13
]}

Lopez-Guerra, J. ^{[14
]}

Livi, L. ^{[4
]}

Baumert, B. G. ^{[10
,20
,21
]}

Vieites, B. ^{[15
]}

Limon, D. ^{[16
]}

Kurman, N. ^{[16
]}

Ko, K. ^{[7
]}

Yu, J. B. ^{[5
]}

Chiang, V. ^{[17
]}

Poortmans, P. ^{[18
,19
]}

Zagar, T. ^{[1
,2
]}

机构：

[1] Univ N Carolina, Dept Radiat Oncol, Chapel Hill, NC 27515 USA

[2] UNC, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27515 USA

[3] Inst Oncol, Radiat Oncol Unit, Rambam Hlth Care Campus, IL-31096 Haifa, Israel

[4] Careggi Univ Florence, Azienda Osped Univ, Radiat Oncol Unit, Florence, Italy

[5] Yale Univ, Sch Med, Dept Therapeut Radiol, New Haven, CT 06510 USA

[6] Radboud Univ Nijmegen, Dept Pathol, Med Ctr, Nijmegen, Netherlands

[7] Thomas Jefferson Univ, Dept Radiat Oncol, Sidney Kimmel Canc Ctr, Philadelphia, PA 19107 USA

[8] Univ Leuven, KU Leuven, Dept Oncol, B-3000 Louvain, Belgium

[9] Univ Hosp Leuven, Dept Radiat Oncol, B-3000 Louvain, Belgium

[10] Univ Bonn, Med Ctr, MediClin Robert Janker Clin & Clin Cooperat Unit, Bonn, Germany

[11] Humanitas Res Hosp, Radiotherapy & Radiosurg Dept, Milan, Italy

[12] UPEC, INSERM, Dept Radiat Oncol, U955,E07, Creteil, France

[13] UPEC, INSERM, Henri Mondor Breast Ctr, U955,E07, Creteil, France

[14] Univ Hosp Virgen del Rocio, Dept Radiat Oncol, Seville, Spain

[15] Univ Hosp Virgen del Rocio, Dept Pathol, Seville, Spain

[16] Rabin Med Ctr, Davidoff Ctr, Inst Oncol, Petah Tiqwa, Israel

[17] Yale Univ, Sch Med, Dept Neurosurg, New Haven, CT USA

[18] Radboud Univ Nijmegen, Dept Radiat Oncol, Med Ctr, Nijmegen, Netherlands

[19] Inst Curie, Dept Radiat Oncol, Paris, France

[20] Paracelsus Clin Osnabrueck, Dept Radiat Oncol, Munster, Germany

[21] Univ Munster, Munster, Germany

来源：

BREAST CANCER RESEARCH AND TREATMENT | 2018年 / 167卷 / 02期

关键词：

Breast cancer; Brain metastases; Molecular subtype; Receptors; Biomarkers; CONSENSUS; RECEPTOR;

D O I：

10.1007/s10549-017-4526-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Discordances between the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), expression between primary breast tumors and their subsequent brain metastases (BM) were investigated in breast cancer patients. We collected retrospective data from 11 institutions in 8 countries in a predefined-standardized format. Receptor status (positive or negative) was determined according to institutional guidelines (immunohistochemically and/or fluorescence in situ hybridization). The study was subject to each institution's ethical research committee. A total of 167 breast cancer patients with BM were included. 25 patients out of 129 with a complete receptor information from both primary tumor and BM (ER, PR, HER2) available, had a change in receptor status: 7 of 26 (27%) ER/PR-positive/HER2-negative primaries (3 gained HER2; 4 lost expression of ER/PR); 10 of 31 (32%) ER/PR-positive/HER2-positive primaries (4 lost ER/PR only; 3 lost HER2 only; 3 lost both ER/PR and HER2); one of 33 (3%) ER/PR-negative receptor/HER2-positive primaries (gained ER); and 7 of 39 (18%) triple-negative primaries (5 gained ER/PR and 2 gained HER2). The majority of breast cancer patients with BM in this series had primary HER2-enriched tumors, followed by those with a triple-negative profile. One out of 5 patients had a receptor discrepancy between the primary tumor and subsequent BM. Therefore, we advise receptor status assessment of BM in all breast cancer patients with available histology as it may have significant implications for therapy.

引用

页码：479 / 483

页数：5

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