Dissecting the Components of Long-Term Potentiation

被引：52

作者：

Blundon, Jay A. ^{[1
,2
]}

Zakharenko, Stanislav S. ^{[1
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Dev Neurobiol, Memphis, TN 38105 USA

[2] Rhodes Coll, Dept Biol, Neurosci Program, Memphis, TN 38112 USA

来源：

NEUROSCIENTIST | 2008年 / 14卷 / 06期

关键词：

LTP; Presynaptic; Postsynaptic; Hippocampus; CA3-CA1; Imaging;

D O I：

10.1177/1073858408320643

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The formation of memories relies in part on plastic changes at synapses between neuronsa Although the mechanisms of synaptic plasticity have been studied extensively over several decades, many aspects of this process remain controversial. The cellular locus of expression of long-term potentiation (LTP) a major form of synaptic plasticity, is one of the most important unresolved phenomena. In this article, some recent advances in this area made possible by the development of new imaging tools are summarized. These studies have demonstrated that LTP is compound in nature and consists of both presynaptic and postsynaptic components. Some features of presynaptic and postsynaptic changes during compound LTP are also reviewed. NEUROSCIENTIST 14(6):598-608, 2008. DOI: 10.1177/1073858408320643

引用

页码：598 / 608

页数：11

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