Effect of Pluronic F127 on the Photosensitizing Properties of Dimegine in the Presence of Nanoparticles

被引：3

作者：

Aksenova, N. A. ^{[1
]}

Kardumyan, V. V. ^{[1
]}

Glagolev, N. N. ^{[1
]}

Shashkova, V. T. ^{[1
]}

Matveeva, I. A. ^{[1
]}

Timashev, P. S. ^{[2
]}

Solov'eva, A. B. ^{[1
]}

机构：

[1] Russian Acad Sci, Semenov Inst Chem Phys, Moscow 119991, Russia

[2] Russian Acad Sci, Inst Laser & Informat Technol, Moscow 117971, Russia

来源：

RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY A | 2015年 / 89卷 / 08期

基金：

俄罗斯科学基金会; 俄罗斯基础研究基金会;

关键词：

porphyrin photosensitizers; nanoparticles; amphiphilic polymers; photooxidation of tryptophan; photodynamic therapy; GOLD NANOPARTICLES; HYDROXYAPATITE PARTICLES; PHOTOTHERMAL THERAPY; PROTEIN ADSORPTION; PORPHYRINS;

D O I：

10.1134/S0036024415080026

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

It is shown that the activity of the water-soluble porphyrin photosensitizer dimegine (DMG) in the oxidation reaction of tryptophan, a test reaction for photodynamic therapy (PDT), can be enhanced by introducing silver, gold, and hydroxyapatite nanoparticles (NP) into the reaction medium if an amphiphilic polymer (AP) with the properties of a SAS is introduced into this mixture. It is concluded that the effect of enhancing the photosensitizing activity of dimegine is due to the formation of nanoparticle-Pluronic-porphyrin triple systems in which Pluronic (PL) plays the role of a bridge, forming complex and adsorption bonds with porphyrin and nanoparticles.

引用

页码：1486 / 1491

页数：6

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