Formation mechanism of dysprosium-doped manganese carbonate nanoparticles by thermal decomposition

被引：7

作者：

Shi, Xin ^{[1
]}

Liu, Kang ^{[1
]}

Wang, Tingjian ^{[2
]}

Zheng, Shunjia ^{[1
]}

Gu, Wei ^{[1
]}

Ye, Ling ^{[1
]}

机构：

[1] Capital Med Univ, Sch Chem Biol & Pharmaceut Sci, Beijing 100069, Peoples R China

[2] Capital Med Univ, Beijing Sanbo Brain Hosp, Dept Neurosurg, Beijing 100093, Peoples R China

来源：

RSC ADVANCES | 2016年 / 6卷 / 101期

基金：

中国国家自然科学基金; 北京市自然科学基金;

关键词：

MRI CONTRAST AGENTS; NEPHROGENIC SYSTEMIC FIBROSIS; OXIDE NANOPARTICLES; MAGNETIC-RESONANCE; MNO NANOPARTICLES; INTRAOPERATIVE MRI; DRUG-DELIVERY; BRAIN GLIOMAS; FLUORESCENCE; FUNCTIONALIZATION;

D O I：

10.1039/c6ra20347g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, dysprosium-doped manganese carbonate nanoparticles (Dy-dopedMnCO(3) NPs) were synthesized by thermal decomposition of Mn-oleate in the presence of Dy-oleate. The evolutional formation of MnCO3 NPs was evidenced by the TEM, Raman and XRD. The formation mechanism of Dy-dopedMnCO(3) NPs was studied for the first time by thermogravimetric-gas chromatography-mass spectrometry coupled with a Fourier transform infrared spectrometer. It was revealed that part of CO2 and H2O produced during the thermal decomposition could be retained by the Dy, which is responsible for the formation of Dy-doped MnCO3 NPs. Additionally, the potential of Dy-doped MnCO3 NPs as an efficient magnetic resonance imaging contrast agent was demonstrated in a brain glioma-bearing mice model.

引用

页码：99339 / 99345

页数：7

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