IMPACT OF TEXTURAL PROPERTIES OF DOUBLE MESOPOROUS CORE-SHELL SILICA NANOSPHERES ON DRUG

Mesoporous silica shell based nanoarchitectures as hollow, solid and rattle type core-mesoporous shell have recently received attentions for their versatile applications in drug delivery, and drug controlled release. Recently we have developed double mesoporous core-shell silica nanospheres by anionic surfactant. However, in this work shell thickness, BET surface area, pore volume and pore size can be tuned by varying synthetic affected accordingly. Double mesoporous core-shell nanospheres were characterized by small angle X-ray Scattering (SAXS), transmission electron microscopy (TEM), and N-2 adsorption-desorption analysis. In that regards, variation of synthetic parameters lead to increment of shell thickness and pore volume from 28 nm to 55 nm and 0.301 to 0.371 cm(3)/g, respectively, which finally caused a drug encapsulation efficiency to be promoted from 10.71 to 20.8%. Furthermore, the drug encapsulation efficiency and release rate were found to be release rate tended to be more controlled with increasing the shell thickness and pore volume.