16-Gy Low-Voltage X-ray Irradiation With Ranibizumab Therapy for AMD: 6-Month Safety and Functional Outcomes

被引:14
作者
Canton, Virgilio Morales [2 ]
Quiroz-Mercado, Hugo [2 ,3 ]
Velez-Montoya, Raul [2 ,3 ]
Lopez-Miranda, Miriam J. [2 ]
Moshfeghi, Andrew A. [4 ]
Shusterman, Eugene M. [5 ]
Kaiser, Peter K. [6 ]
Sanislo, Steven R. [1 ]
Gertner, Michael [5 ]
Moshfeghi, Darius M. [1 ]
机构
[1] Stanford Univ, Sch Med, Byers Eye Inst, Dept Ophthalmol,Horngren Family Vitreoretinal Ctr, Palo Alto, CA 94303 USA
[2] IAP, Assoc Evitar Ceguera Mexico, Mexico City, DF, Mexico
[3] Univ Colorado, Dept Ophthalmol, Denver, CO 80202 USA
[4] Univ Miami, Miller Sch Med, Dept Ophthalmol, Bascom Palmer Eye Inst, Palm Beach Gardens, FL USA
[5] Oraya Therapeut Inc, Newark, CA USA
[6] Cleveland Clin, Cole Eye Inst, Cleveland, OH 44106 USA
关键词
SUBFOVEAL CHOROIDAL NEOVASCULARIZATION; EXTERNAL-BEAM IRRADIATION; MACULAR DEGENERATION; RADIATION RETINOPATHY; PLAQUE RADIOTHERAPY; STEREOTACTIC RADIOSURGERY; BRACHYTHERAPY; BEVACIZUMAB; MEMBRANES; SECONDARY;
D O I
10.3928/15428877-20110804-01
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
BACKGROUND AND OBJECTIVE: To describe the 6-month safety and preliminary efficacy outcomes of the use of 16-Gy radiation with intravitreal ranibizumab for patients with neovascular age-related macular degeneration (AMD). PATIENTS AND METHODS: A single treatment of a non-invasive, externally delivered low-voltage 16-Gy x-ray irradiation was administered in one session through three locations in the inferior pars plana. Optical coherence tomography (OCT) and Early Treatment Diabetic Retinopathy Study (ETDRS) visual acuity (VA) examinations were performed at 1 week, 1 month, and monthly thereafter, with quarterly fluorescein angiography (FA). After the two initial ranibizumab injections, subsequent injections were administered according to the following criteria: VA decline of 10 ETDRS letters compared with baseline, increase of 100-mu m central foveal thickness on OCT compared with baseline, the development of new submacular hemorrhage, and the development of a new area of classic choroidal neovascularization on FA. RESULTS: Twenty-six patients completed a 6-month follow-up. There was no evidence of radiation retinopathy, optic neuropathy, or cataract. The mean baseline ETDRS score was 46.6 letters (range: 5 to 80; standard deviation [SD]: 21.5). At 6 months, the corresponding ETDRS score was 55.6 letters (range: 25 to 80; SD: 18.9) and the mean change in VA was 9.5 ETDRS letters (SD: 10.3). On responder analysis, 96% lost 15 or fewer ETDRS letters, 81% gained 0 or more ETDRS letters, and 50% gained 15 or more ETDRS letters. Patients received a total of 13 ranibizumab injections following two initial injections. At 6 months, patients received an average of 0.5 additional injections following the initial two mandated injections. CONCLUSION: A single treatment of externally applied, non-invasive 16-Gy low-voltage x-ray therapy in conjunction with ranibizumab demonstrated an overall improvement of VA in patients with neovascular AMD at 6 months with no radiation-related adverse effects.
引用
收藏
页码:468 / 473
页数:6
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