Chemical genetics: Drug screens in zebrafish

被引：72

作者：

den Hertog, J ^{[1
]}

机构：

[1] Netherlands Inst Dev Biol, Hubrecht Lab, NL-3584 CT Utrecht, Netherlands

来源：

BIOSCIENCE REPORTS | 2005年 / 25卷 / 5-6期

关键词：

chemical genetics; zebrafish; development; compounds; inhibitors; drug target; disease;

D O I：

10.1007/s10540-005-2891-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

High throughput chemical genetic screens for compounds with specific biological activity in a whole organism are feasible using zebrafish embryos. At least two medium to large scale drug screens have been carried out to date, leading to the identification of compounds that disturb zebrafish development. Chemical genetics using zebrafish embryos may become an important step in the discovery of drugs and their targets.

引用

页码：289 / 297

页数：9

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