Massive release of the histamine-degrading enzyme diamine oxidase during severe anaphylaxis in mastocytosis patients

被引:34
作者
Boehm, Thomas [1 ]
Reiter, Birgit [2 ]
Ristl, Robin [3 ]
Petroczi, Karin [1 ]
Sperr, Wolfgang [4 ]
Stimpfl, Thomas [2 ]
Valent, Peter [4 ]
Jilma, Bernd [1 ]
机构
[1] Med Univ Vienna, Dept Clin Pharmacol, Vienna, Austria
[2] Med Univ Vienna, Lab Med, Clin Inst, Analyt Toxicol, Vienna, Austria
[3] Med Univ Vienna, Ctr Med Stat Informat & Intelligent Syst, Sect Med Stat IMS, Vienna, Austria
[4] Med Univ Vienna, Div Hematol & Hemostaseol & Ludwig Boltzmann Clus, Dept Internal Med 1, Vienna, Austria
关键词
anaphylaxis; diamine oxidase; heparin; histamine degradation; mastocytosis; MAST-CELL ACTIVATION; SERUM TRYPTASE; DESTROYING FACTOR; DIAGNOSTIC-VALUE; GRADING SYSTEM; PLASMA; BLOOD; HEPARIN; CLASSIFICATION; ANTICOAGULANT;
D O I
10.1111/all.13663
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Background Histaminolytic activity mediated by diamine oxidase (DAO) is present in plasma after induction of severe anaphylaxis in rats, guinea pigs, and rabbits. Heparin released during mast cell degranulation in the gastrointestinal tract might liberate DAO from heparin-sensitive storage sites. DAO release during anaphylaxis has not been demonstrated in humans. Methods Plasma DAO, tryptase, and histamine concentrations of four severe anaphylaxis events were determined at multiple serial time points in two patients with systemic mastocytosis. The histamine degradation rates were measured in anaphylaxis samples and in pregnancy sera and plasma with comparable DAO concentrations. Results Mean DAO (132 ng/mL) and tryptase (304 ng/mL) concentrations increased 187- and 4.0-fold, respectively, over baseline values (DAO 0.7 ng/mL, tryptase 76 ng/mL) during severe anaphylaxis. Under non-anaphylaxis conditions, DAO concentrations were not elevated in 29 mastocytosis patients compared to healthy volunteers and there was no correlation between DAO and tryptase levels in mastocytosis patients. The histamine degradation rate of DAO in plasma from mastocytosis patients during anaphylaxis is severely compromised compared to DAO from pregnancy samples. Conclusion During severe anaphylaxis in mastocytosis patients, DAO is likely released from heparin-sensitive gastrointestinal storage sites. The measured concentrations can degrade histamine, but DAO activity is compromised compared to pregnancy samples. For accurate histamine measurements during anaphylaxis, DAO inhibition is essential to inhibit further histamine degradation after blood withdrawal. Determination of DAO antigen levels might be of clinical value to improve the diagnosis of mast cell activation.
引用
收藏
页码:583 / 593
页数:11
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