The Effects of Transoral Incisionless Fundoplication on Chronic GERD Patients: 12-Month Prospective Multicenter Experience

被引：28

作者：

Wilson, Erik B. ^{[1
]}

Barnes, William E. ^{[4
]}

Mavrelis, Peter G. ^{[5
]}

Carter, Bart J. ^{[6
]}

Bell, Reginald C. W. ^{[8
]}

Sewell, Robert W. ^{[2
]}

Ihde, Glenn M. ^{[3
]}

Dargis, David ^{[9
]}

Hoddinott, Kevin M. ^{[10
]}

Shughoury, Ahmad B. ^{[5
]}

Gill, Brian D. ^{[11
]}

Fox, Mark A. ^{[12
]}

Turgeon, Daniel G. ^{[13
,14
]}

Freeman, Katherine D. ^{[8
]}

Gunsberger, Tanja ^{[7
]}

Hausmann, Mark G. ^{[15
]}

LeBlanc, Karl A. ^{[15
]}

Deljkich, Emir ^{[16
]}

Trad, Karim S. ^{[13
,14
]}

机构：

[1] Univ Texas Hlth Sci Ctr Houston, Dept Surg, Houston, TX 77030 USA

[2] Master Ctr Minimally Invas Surg, Southlake, TX USA

[3] Ihde Surg Grp, Arlington, TX USA

[4] Livingston Hosp & Healthcare Serv Inc, CAH, Salem, KY USA

[5] Internal Med Associates, Merrillville, IN USA

[6] Mt Graham Reg Med Ctr, Safford, AZ USA

[7] Tempe St Lukes Hosp, Tempe, AZ USA

[8] SurgOne Foregut Inst, Englewood, CO USA

[9] Allegan Surg Associates, Allegan, MI USA

[10] Munroe Reg Med Ctr, Ocala, FL USA

[11] Utah Cty Surg Associates, Orem, UT USA

[12] Crossville Med Grp PA, Crossville, TN USA

[13] George Washington Univ, Sch Med & Hlth Sci, Dept Surg, Washington, DC 20052 USA

[14] Reston Surg Associates, Reston, VA USA

[15] Surg Grp Baton Rouge, Baton Rouge, LA USA

[16] EndoGastr Solut Inc, Redmond, WA USA

来源：

SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES | 2014年 / 24卷 / 01期

关键词：

regurgitation; TIF; EsophyX; GERD; fundoplication; heartburn; GASTROESOPHAGEAL-REFLUX DISEASE; LAPAROSCOPIC NISSEN FUNDOPLICATION; PUMP INHIBITOR THERAPY; QUALITY-OF-LIFE; DOUBLE-BLIND; ENDOSCOPIC FUNDOPLICATION; ANTIREFLUX SURGERY; ATYPICAL SYMPTOMS; CONTROLLED-TRIAL; ACID REFLUX;

D O I：

10.1097/SLE.0b013e3182a2b05c

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Purpose: This study aimed to assess the impact of transoral incisionless fundoplication (TIF) on patients with chronic gastroesophageal reflux disease (GERD) at 12-month follow-up. Methods: Clinical outcomes of 100 consecutive patients with chronic GERD who underwent TIF between January 2010 and February 2011 were analyzed. Results: There were no major complications reported. Esophageal acid exposure was normalized in 14/27 (52%) of patients who underwent 12-month pH testing. Seventy-four percent of all patients were off proton pump inhibitors versus 92% on daily proton pump inhibitors before TIF, P < 0.001. Daily bothersome heartburn and regurgitation symptoms were eliminated in 66/85 (78%) and 48/58 (83%) of patients. Median reflux symptom index score was reduced from 20 (0 to 41) to 5 (0 to 44), P < 0.001. Two patients reported de novo dysphagia and 1 patient reported bloating (scores 0 to 3). Six patients underwent revision; 5 laparoscopic Nissen fundoplication and 1 TIF. Conclusions: TIF provided a safe and effective therapeutic option for carefully selected patients with chronic GERD.

引用

页码：36 / 46

页数：11

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