Association of adiponectin (AdipoQ) and sulphonylurea receptor (ABCC8) gene polymorphisms with Type 2 Diabetes in North Indian population of Punjab

被引:37
作者
Matharoo, Kawaljit [1 ]
Arora, Punit [2 ]
Bhanwer, A. J. S. [1 ]
机构
[1] Guru Nanak Dev Univ, Dept Human Genet, Amritsar 143005, Punjab, India
[2] Diabet Clin & Res Inst, Amritsar 143002, Punjab, India
关键词
Adiponectin; PCR-RFLP; Sulphonylurea receptor; T2D; SEQUENCE VARIANTS; GLUCOSE-INTOLERANCE; PLASMA ADIPONECTIN; INSULIN-RESISTANCE; PROXIMAL PROMOTER; JAPANESE PATIENTS; APM1; GENE; OBESITY; RISK; KCNJ11;
D O I
10.1016/j.gene.2013.05.075
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
In Type 2 Diabetes (T2D), adiponectin (AdipoQ) and sulphonylurea receptor genes (ABCC8) are important targets for candidate gene association studies. The single nucleotide polymorphisms (SNPs) in these genes have been associated with features of the metabolic syndrome across various populations. The present case-control study undertaken in the population of Punjab, evaluates the association of +45T>G polymorphism in AdipoQ gene; and Exon16-3C>T as well as Exon18C>T polymorphisms in ABCC8 gene with T2D. These SNPs were geno-typed in 200 T2D cases and 200 non-diabetic healthy controls using the PCR-RFLP method. The frequency of the minor G-allele for AdipoQ+45(T>G) polymorphism was significantly higher in T2D cases (29.0%) than in controls (21.5%) [P = 0.02, OR = 1.49 (1.07-2.04)]. The genetic model analysis revealed that the G-allele cumulatively provides nearly 1.59-1.78 fold increased risk to T2D under the additive (P = 0.009; OR = 1.59, 1.12-225 at 95% CI), dominant (TG/GG vs. TT) (P = 0.034, OR = 1.64, 1.04-2.56 at 95% Cl) and codominant model (TG vs. TT/GG) (P = 0.014; OR = 1.78, 1.12-2.82 at 95% CI) after adjusting for confounding factors. However, no difference in the distribution of genotype and allele frequencies was observed for both the ABCC8 polymorphisms. The distribution of obesity profiles (BMI, WC and WHR) was also significantly different between cases and controls (P < 0.05). Higher BMI and central obesity were observed to increase the risk of T2D. G-allele of +45(T>G) polymorphism in the adiponectin gene appears to be associated with increased risk of 12D, but the polymorphisms in sulphonylurea receptor gene do not seem to be associated with T2D in the population of Punjab. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码:228 / 234
页数:7
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