Peculiar Aspects in Influence of α1-Adrenoceptor Stimulation on Isolated Rat Heart

被引：5
作者：
Zefirov, T. L. [1 ]
Khabibrakhmanov, I. I. [1 ]
Ziyatdinova, N. I. [1 ]
Zefirov, A. L. [2 ]
机构：
[1] Kazan Volga Reg Fed Univ, Dept Human Hlth Protect, Kazan, Russia
[2] Kazan Fed Med Univ, Dept Normal Physiol, Kazan, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2016年 / 162卷 / 01期
基金：
俄罗斯基础研究基金会;
关键词：
heart; chronotropy; alpha(1)-adrenoceptor; methoxamine; rat; CARDIAC-FUNCTION; BLOCKADE; RECEPTORS; SYSTEM;
D O I：
10.1007/s10517-016-3530-z
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The study examined the effect of alpha(1)-adrenoceptor stimulation with methoxamine on chronotropic function of isolated heart perfused ex vivo according to Langendorff and cardiac chronotropy in vivo. Stimulation of alpha(1)-adrenoceptors in isolated heart induced gradually developing bradycardia, which progressed during several minutes. Similar stimulation in vivo produced a short-term bradycardia probably terminated by the compensatory influences in the whole organism. Comparison of the data obtained in both experimental paradigms during alpha(1)-adrenoceptor stimulation revealed unidirectional changes in cardiac chronotropy characterized with time-related peculiarities.
引用
收藏
页码：4 / 6
页数：3
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