Gout - a guide for the general and acute physicians

被引：103

作者：

Abhishek, Abhishek ^{[1
,2
]}

Roddy, Edward ^{[3
,4
]}

Doherty, Michael ^{[1
]}

机构：

[1] Univ Nottingham, Rheumatol, Nottingham, England

[2] Univ Nottingham, Nottingham, England

[3] Keele Univ, Rheumatol, Keele, Staffs, England

[4] Keele Univ, Arthrit Res UK Primary Care Ctr, Keele, Staffs, England

来源：

CLINICAL MEDICINE | 2017年 / 17卷 / 01期

关键词：

colchicine; gout; hyperuricaemia; tophi; urate-lowering treatment; EVIDENCE BASED RECOMMENDATIONS; SERUM URIC-ACID; CONTROLLED-TRIALS; TASK-FORCE; HYPERURICEMIA; MANAGEMENT; POPULATION; RHEUMATOLOGY; METAANALYSIS; ESCISIT;

D O I：

10.7861/clinmedicine.17-1-54

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Gout is the most prevalent inflammatory arthritis and affects 2.5% of the general population in the UK. It is also the only arthritis that has the potential to be cured with safe, inexpensive and well tolerated urate-lowering treatments, which reduce serum uric acid by either inhibiting xanthine oxidase - eg allopurinol, febuxostat - or by increasing the renal excretion of uric acid. Of these, xanthine oxidase inhibitors are used first line and are effective in 'curing' gout in the vast majority of patients. Gout can be diagnosed on clinical grounds in those with typical podagra. However, in those with involvement of other joints, joint aspiration is recommended to demonstrate monosodium urate crystals and exclude other causes of acute arthritis, such as septic arthritis. However, a clinical diagnosis of gout can be made if joint aspiration is not feasible. This review summarises the current understanding of the pathophysiology, clinical presentation, investigations and treatment of gout.

引用

页码：54 / 59

页数：6

共 24 条

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