Probing 3-Hydroxyflavone for In Vitro Glycorandomization of Flavonols by YjiC

被引：50

作者：

Pandey, Ramesh Prasad ^{[1
]}

Parajuli, Prakash ^{[1
]}

Koirala, Niranjan ^{[1
]}

Park, Je Won ^{[1
]}

Sohng, Jae Kyung ^{[1
]}

机构：

[1] Sun Moon Univ, IBR, Dept Pharmaceut Engn, Asan, Chungnam, South Korea

来源：

APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 2013年 / 79卷 / 21期

关键词：

QUERCETIN; GLYCOSIDES; MECHANISM;

D O I：

10.1128/AEM.02057-13

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The glycosylation of five different flavonols, fisetin, quercetin, myricetin, kaempferol, and 3-hydroxyflavone, was achieved by applying YjiC. 3-Hydroxyflavone was selected as a probe for in vitro glycorandomization of all flavonols using diverse nucleotide diphosphate-D/L-sugars. This study unlocked the possibilities of the glycodiversification of flavonols and the generation of novel compounds as future therapeutics.

引用

页码：6833 / 6838

页数：6

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